ID   Y2594_STRCO             Reviewed;         602 AA.
AC   Q9L1I2;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Exopolysaccharide phosphotransferase SCO2594;
DE            EC=2.7.-.-;
DE   AltName: Full=Stealth protein SCO2594;
GN   OrderedLocusNames=SCO2594; ORFNames=SCC88.05c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
RN   [2]
RP   IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX   PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA   Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT   "Stealth proteins: in silico identification of a novel protein family
RT   rendering bacterial pathogens invisible to host immune defense.";
RL   PLoS Comput. Biol. 1:492-499(2005).
CC   -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC       conserved from bacteria to higher eukaryotes. Family members were first
CC       identified in microbes as proteins that help pathogens to elude the
CC       host innate immune system. Microbial stealth proteins are involved in
CC       the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC       to function as hexose-1-phosphoryltransferases.
CC   -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
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DR   EMBL; AL939113; CAB75375.1; -; Genomic_DNA.
DR   RefSeq; NP_626831.1; NC_003888.3.
DR   RefSeq; WP_003976207.1; NZ_VNID01000001.1.
DR   AlphaFoldDB; Q9L1I2; -.
DR   STRING; 100226.SCO2594; -.
DR   GeneID; 1098028; -.
DR   KEGG; sco:SCO2594; -.
DR   PATRIC; fig|100226.15.peg.2640; -.
DR   eggNOG; COG0438; Bacteria.
DR   HOGENOM; CLU_033996_0_0_11; -.
DR   InParanoid; Q9L1I2; -.
DR   OMA; YHEEAAN; -.
DR   PhylomeDB; Q9L1I2; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031358; Stealth_CR1.
DR   InterPro; IPR021520; Stealth_CR2.
DR   InterPro; IPR031357; Stealth_CR3.
DR   InterPro; IPR031356; Stealth_CR4.
DR   Pfam; PF17101; Stealth_CR1; 1.
DR   Pfam; PF11380; Stealth_CR2; 1.
DR   Pfam; PF17102; Stealth_CR3; 1.
DR   Pfam; PF17103; Stealth_CR4; 1.
PE   3: Inferred from homology;
KW   Exopolysaccharide synthesis; Reference proteome; Transferase.
FT   CHAIN           1..602
FT                   /note="Exopolysaccharide phosphotransferase SCO2594"
FT                   /id="PRO_0000235960"
FT   REGION          251..271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   602 AA;  67502 MW;  720EAB86A31D943F CRC64;
     MRNPEAPRLV GVYRRVVPVG ARRVIAEHVD SGFRQQVKEG IAAAAAKRDQ INRVRVARSH
     RKLLARHDRR VVSVGKAPRI AHVVPRATPL DARRANLDDV TEALRHAGID YFCVRSASET
     STAVAVREDD REHVITALRQ ACRVRPGYVI PVGKGEPLDE AALPAFGTGP WKRVSGSPVF
     RCTWYRTDET GRMVFGLRYG CDIEFWHQEG GELVSPRRNP VAEAVPVEEE ATEADESLFT
     DLAPLPEDRI PRAGEDLDAG DGAAGGPRPG LVRTRPAFAA GSVGRRTFPI DVVYTWVDGS
     DPAWIRSRAE FSDRPYHEEA ANAARYLSRD ELRYSLRSLN LYAPWVRNIY LVTADQTPDW
     LNTDHPRLKV VSHKEIFSEP TSLPTFNSHA IESQLHHIDG LSEHFLYFND DVMLGRETLP
     QHFFLPNGLG QYYLSPALIP FGEPNSEDPP VAAAGKNNRR LIAERFGGST IFRKMKHVPH
     ALHRGVLEAI ETDFADEHRR TAASRFRSAG DISVTSSLHH YYAFHTGRSF PGDQLVYRYL
     DVGKPGAERV LGRLLAEREA HVFCLNDTTS TESELAHQQA LMTRFLDEYF PFPSPYERGA
     DD