ID   Y2599_MYCTU             Reviewed;         143 AA.
AC   P9WL69; L0TA52; Q50622;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Uncharacterized protein Rv2599;
DE   Flags: Precursor;
GN   OrderedLocusNames=Rv2599; ORFNames=MTCY227.02c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL123456; CCP45395.1; -; Genomic_DNA.
DR   PIR; F70727; F70727.
DR   RefSeq; NP_217115.1; NC_000962.3.
DR   RefSeq; WP_003899390.1; NZ_NVQJ01000023.1.
DR   AlphaFoldDB; P9WL69; -.
DR   SMR; P9WL69; -.
DR   STRING; 83332.Rv2599; -.
DR   PaxDb; P9WL69; -.
DR   DNASU; 887832; -.
DR   GeneID; 887832; -.
DR   KEGG; mtu:Rv2599; -.
DR   TubercuList; Rv2599; -.
DR   eggNOG; ENOG5032994; Bacteria.
DR   OMA; PCSIRVE; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR025341; DUF4247.
DR   Pfam; PF14042; DUF4247; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..143
FT                   /note="Uncharacterized protein Rv2599"
FT                   /id="PRO_0000014143"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   143 AA;  14955 MW;  62ECCF049826B588 CRC64;
     MSRNRLFLVA GSLAVAAAVS LISGITLLNR DVGSYIASHY RQESRDVNGT RYLCTGSPKQ
     VATTLVKYQT PAARASHTDT EYLRYRNNIV TVGPDGTYPC IIRVENLSAG YNHGAYVFLG
     PGFTPGSPSG GSGGSPGGPG GSK