ID   Y2603_MYCTU             Reviewed;         251 AA.
AC   P9WGA5; L0TA55; O33214; P67177;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Probable transcriptional regulatory protein Rv2603c {ECO:0000255|HAMAP-Rule:MF_00693};
GN   OrderedLocusNames=Rv2603c; ORFNames=MTCI270A.02;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00693}.
CC   -!- SIMILARITY: Belongs to the TACO1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00693}.
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DR   EMBL; AL123456; CCP45400.1; -; Genomic_DNA.
DR   PIR; F70500; F70500.
DR   RefSeq; NP_217119.1; NC_000962.3.
DR   RefSeq; WP_003413464.1; NZ_NVQJ01000023.1.
DR   AlphaFoldDB; P9WGA5; -.
DR   SMR; P9WGA5; -.
DR   STRING; 83332.Rv2603c; -.
DR   PaxDb; P9WGA5; -.
DR   DNASU; 887369; -.
DR   GeneID; 45426606; -.
DR   GeneID; 887369; -.
DR   KEGG; mtu:Rv2603c; -.
DR   TubercuList; Rv2603c; -.
DR   eggNOG; COG0217; Bacteria.
DR   OMA; ETIMYEG; -.
DR   PhylomeDB; P9WGA5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.200; -; 1.
DR   Gene3D; 3.30.70.980; -; 2.
DR   HAMAP; MF_00693; Transcrip_reg_TACO1; 1.
DR   InterPro; IPR017856; Integrase-like_N.
DR   InterPro; IPR002876; Transcrip_reg_TACO1-like.
DR   InterPro; IPR026564; Transcrip_reg_TACO1-like_dom3.
DR   InterPro; IPR029072; YebC-like.
DR   PANTHER; PTHR12532; PTHR12532; 1.
DR   Pfam; PF01709; Transcrip_reg; 1.
DR   SUPFAM; SSF75625; SSF75625; 1.
DR   TIGRFAMs; TIGR01033; TIGR01033; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..251
FT                   /note="Probable transcriptional regulatory protein Rv2603c"
FT                   /id="PRO_0000175853"
SQ   SEQUENCE   251 AA;  26799 MW;  B163D43729A06B33 CRC64;
     MSGHSKWATT KHKKAVVDAR RGKMFARLIK NIEVAARVGG GDPAGNPTLY DAIQKAKKSS
     VPNENIERAR KRGAGEEAGG ADWQTIMYEG YAPNGVAVLI ECLTDNRNRA ASEVRVAMTR
     NGGTMADPGS VSYLFSRKGV VTLEKNGLTE DDVLAAVLEA GAEDVNDLGD SFEVISEPAE
     LVAVRSALQD AGIDYESAEA SFQPSVSVPV DLDGARKVFK LVDALEDSDD VQNVWTNVDV
     SDEVLAALDD E