Y2609_MYCBO
ID Y2609_MYCBO Reviewed; 340 AA.
AC P65024; A0A1R3Y1V2; Q50643; X2BLC7;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Uncharacterized protein Mb2609c;
GN OrderedLocusNames=BQ2027_MB2609C;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000305};
CC Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC cysteines and an exchangeable S-adenosyl-L-methionine. {ECO:0000305};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; LT708304; SIU01227.1; -; Genomic_DNA.
DR RefSeq; NP_856255.1; NC_002945.3.
DR RefSeq; WP_003413359.1; NC_002945.4.
DR AlphaFoldDB; P65024; -.
DR EnsemblBacteria; SIU01227; SIU01227; BQ2027_MB2609C.
DR GeneID; 45426580; -.
DR PATRIC; fig|233413.5.peg.2870; -.
DR OMA; GNTDCYQ; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR006638; Elp3/MiaB/NifB.
DR InterPro; IPR040086; MJ0683-like.
DR InterPro; IPR007197; rSAM.
DR PANTHER; PTHR43432; PTHR43432; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SFLD; SFLDG01084; Uncharacterised_Radical_SAM_Su; 1.
DR SMART; SM00729; Elp3; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S; Cell membrane; Iron; Iron-sulfur; Membrane; Metal-binding;
KW S-adenosyl-L-methionine; Transmembrane; Transmembrane helix.
FT CHAIN 1..340
FT /note="Uncharacterized protein Mb2609c"
FT /id="PRO_0000104062"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 58..307
FT /note="Radical SAM core"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01266"
FT BINDING 72
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="4Fe-4S-S-AdoMet"
FT /evidence="ECO:0000255"
FT BINDING 76
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="4Fe-4S-S-AdoMet"
FT /evidence="ECO:0000255"
FT BINDING 79
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="4Fe-4S-S-AdoMet"
FT /evidence="ECO:0000255"
SQ SEQUENCE 340 AA; 37176 MW; 504623D48273E2D9 CRC64;
MRWARQAVAV NGMPVDDGAL PGLQRIGLVR SVRAPQFDGI TFHEVLCKSA LNKVPNAAAL
PFRYTVNGYR GCSHACRYCF ARPTHEYLDF NPGTDFDTQV VVKTNVAAVL RHELRRPSWR
RETVALGTNT DPYQRAEGRY ALMPGIIGAL AASGTPLSIL TKGTLLRRDL PLIAEAAQQV
PVSVAVSLAV GDPELHRDVE SGTPTPQARL ALITAIRAAG LDCHVMVAPV LPQLTDSGEH
LDQLLGQIAA AGATGVTVFG LHLRGSTRGW FMCWLARAHP ELVSRYRELY RRGPYLPPSY
REMLRERVAP LIAKYRLAGD HRPAPPETEA ALVPVQATLF
