ID   Y2613_METAC             Reviewed;         424 AA.
AC   Q8TMP0; Q8TMP1;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 2.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Uncharacterized serpin-like protein MA_2613/MA_2612;
GN   OrderedLocusNames=MA_2613/MA_2612;
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM05993.1; Type=Frameshift; Note=Produces two ORFs.; Evidence={ECO:0000305};
CC       Sequence=AAM05994.1; Type=Frameshift; Note=Produces two ORFs.; Evidence={ECO:0000305};
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DR   EMBL; AE010299; AAM05994.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AE010299; AAM05993.1; ALT_FRAME; Genomic_DNA.
DR   AlphaFoldDB; Q8TMP0; -.
DR   SMR; Q8TMP0; -.
DR   EnsemblBacteria; AAM05993; AAM05993; MA_2612.
DR   EnsemblBacteria; AAM05994; AAM05994; MA_2613.
DR   KEGG; mac:MA_2612; -.
DR   KEGG; mac:MA_2613; -.
DR   HOGENOM; CLU_2597669_0_0_2; -.
DR   InParanoid; Q8TMP0; -.
DR   PhylomeDB; Q8TMP0; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR015557; Serpin_B1.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   PANTHER; PTHR11461:SF180; PTHR11461:SF180; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
PE   3: Inferred from homology;
KW   Protease inhibitor; Reference proteome; Serine protease inhibitor.
FT   CHAIN           1..424
FT                   /note="Uncharacterized serpin-like protein MA_2613/MA_2612"
FT                   /id="PRO_0000094161"
FT   SITE            372..373
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   424 AA;  48734 MW;  6E63AA3521092CA5 CRC64;
     MKTLLIFTLT LLCSGCLEDT AVTPINTINP DSVEYYGVAA ANNAFAFDMY SKLVQLESRE
     KNNILFSPYS VSAAMAICYE GTEGTAKEQI SNVFYFPANN TVFKVRLKET NDKVYSGSDG
     YELENANAIW VQEEYPVKEE YIFNVKNYYR SEVTNLDFVE KPDESRDAIN EWVEDKTDRK
     IKDIVPKGSI TDDTRLILTN AIYFNGKWEH EFDKKMTSKK TFYPTKREEV SVDMMYISSN
     FNYSENLKAK IIELPYKGND LSMYIVLPKG NNITEFENNF TVNEYTELKY NMESLGDVET
     SIPKFKFETK TELSDSLIEM GVADAFDLKL ANFSGISEIR LLISRMIHQD FIDVQEEVTE
     AAASTTVFIG SVSSSKSKSR EFKADLPFIF FIEDRRTDCI LFMGKVEYPE YEGTGRFWSL
     PWNK