ID   Y2625_STRCO             Reviewed;         413 AA.
AC   Q9F309;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Uncharacterized N-acetyltransferase SCO2625 {ECO:0000255|HAMAP-Rule:MF_01812};
DE            EC=2.3.1.- {ECO:0000255|HAMAP-Rule:MF_01812};
GN   OrderedLocusNames=SCO2625; ORFNames=SCC80.10;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- SUBUNIT: Homohexamer; trimer of dimers. {ECO:0000255|HAMAP-
CC       Rule:MF_01812}.
CC   -!- SIMILARITY: Belongs to the acetyltransferase Eis family.
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DR   EMBL; AL939113; CAC10001.1; -; Genomic_DNA.
DR   RefSeq; NP_626861.1; NC_003888.3.
DR   RefSeq; WP_011028461.1; NZ_VNID01000001.1.
DR   AlphaFoldDB; Q9F309; -.
DR   SMR; Q9F309; -.
DR   STRING; 100226.SCO2625; -.
DR   GeneID; 1098059; -.
DR   KEGG; sco:SCO2625; -.
DR   PATRIC; fig|100226.15.peg.2671; -.
DR   eggNOG; COG4552; Bacteria.
DR   HOGENOM; CLU_050659_0_0_11; -.
DR   InParanoid; Q9F309; -.
DR   OMA; WNEGRWR; -.
DR   PhylomeDB; Q9F309; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0034069; F:aminoglycoside N-acetyltransferase activity; IBA:GO_Central.
DR   GO; GO:0030649; P:aminoglycoside antibiotic catabolic process; IBA:GO_Central.
DR   Gene3D; 3.30.1050.10; -; 1.
DR   HAMAP; MF_01812; Eis; 1.
DR   InterPro; IPR041380; Acetyltransf_17.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR025559; Eis_dom.
DR   InterPro; IPR000182; GNAT_dom.
DR   InterPro; IPR022902; NAcTrfase_Eis.
DR   InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR   Pfam; PF17668; Acetyltransf_17; 1.
DR   Pfam; PF13530; SCP2_2; 1.
DR   SUPFAM; SSF55718; SSF55718; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..413
FT                   /note="Uncharacterized N-acetyltransferase SCO2625"
FT                   /id="PRO_0000220266"
FT   DOMAIN          3..155
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01812"
FT   ACT_SITE        127
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01812"
FT   ACT_SITE        413
FT                   /note="Proton acceptor; via carboxylate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01812"
FT   BINDING         86..88
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01812"
FT   BINDING         94..99
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01812"
FT   BINDING         122..123
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01812"
SQ   SEQUENCE   413 AA;  44719 MW;  29869DA00AD7AB0A CRC64;
     MTMEPRVLRR EEWDSWYGSL IRAFGGVPEP AEELELFREL TRVDRSIGVW ERDGEAEACV
     GTTGSFDFRM TVPGGAQVRA AGVTMVSVAA THRRRGVLTS MMRRQLDDVR AWGEPLAVLT
     ASEPAIYGRF GYGAATFSLS AEIDTSRVRL SVPAGTDDVR LRYAAPADVL DACEAVYARL
     VPGRPGMLAR RPGWERLALL DPESGRDGAS PLQCVVARRG GEVTGFARFR VRPAWGPEGA
     GGTVVLDDLA GLDPATEAAL WRFLYDVDLT SRLAVRGRPV DEAWQYQVSD IRRCRPESRD
     ALYVRLVDVG AALAARTYQA PVDVVFEVED AFCPWNAGRW RLSGDAKGAS CERTSDGADL
     ALSVRELGAA YLGGVRLSSL GAAGRVREVR AGALAEASVG FGSDVAPWLP HGF