Y2627_MYCTU
ID Y2627_MYCTU Reviewed; 413 AA.
AC P9WL67; L0TA72; O06185; Q7D6V3;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 36.
DE RecName: Full=Uncharacterized protein Rv2627c;
GN OrderedLocusNames=Rv2627c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP INDUCTION BY HYPOXIA.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=11416222; DOI=10.1073/pnas.121172498;
RA Sherman D.R., Voskuil M., Schnappinger D., Liao R., Harrell M.I.,
RA Schoolnik G.K.;
RT "Regulation of the Mycobacterium tuberculosis hypoxic response gene
RT encoding alpha -crystallin.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7534-7539(2001).
RN [3]
RP INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, AND DORMANCY REGULON.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=12953092; DOI=10.1084/jem.20030205;
RA Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA Sherman D.R., Schoolnik G.K.;
RT "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT tuberculosis dormancy program.";
RL J. Exp. Med. 198:705-713(2003).
RN [4]
RP BIOTECHNOLOGY.
RX PubMed=16931093; DOI=10.1016/j.micinf.2006.03.018;
RA Leyten E.M., Lin M.Y., Franken K.L., Friggen A.H., Prins C.,
RA van Meijgaarden K.E., Voskuil M.I., Weldingh K., Andersen P.,
RA Schoolnik G.K., Arend S.M., Ottenhoff T.H., Klein M.R.;
RT "Human T-cell responses to 25 novel antigens encoded by genes of the
RT dormancy regulon of Mycobacterium tuberculosis.";
RL Microbes Infect. 8:2052-2060(2006).
RN [5]
RP INDUCTION BY CARBON MONOXIDE (CO).
RC STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX PubMed=18474359; DOI=10.1016/j.chom.2008.03.007;
RA Shiloh M.U., Manzanillo P., Cox J.S.;
RT "Mycobacterium tuberculosis senses host-derived carbon monoxide during
RT macrophage infection.";
RL Cell Host Microbe 3:323-330(2008).
RN [6]
RP INDUCTION BY CARBON MONOXIDE (CO), AND DORMANCY REGULON.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=18400743; DOI=10.1074/jbc.m802274200;
RA Kumar A., Deshane J.S., Crossman D.K., Bolisetty S., Yan B.S., Kramnik I.,
RA Agarwal A., Steyn A.J.;
RT "Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium
RT tuberculosis dormancy regulon.";
RL J. Biol. Chem. 283:18032-18039(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- INDUCTION: A member of the dormancy regulon. Induced in response to
CC reduced oxygen tension (hypoxia), low levels of nitric oxide (NO) and
CC carbon monoxide (CO). It is hoped that this regulon will give insight
CC into the latent, or dormant phase of infection.
CC {ECO:0000269|PubMed:11416222, ECO:0000269|PubMed:12953092,
CC ECO:0000269|PubMed:18400743, ECO:0000269|PubMed:18474359}.
CC -!- BIOTECHNOLOGY: Has strong T-cell and IFN-gamma inducing capacity in
CC human tuberculin skin test positive patients, indicating this might be
CC a good vaccine candidate. {ECO:0000269|PubMed:16931093}.
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DR EMBL; AL123456; CCP45425.1; -; Genomic_DNA.
DR PIR; B70573; B70573.
DR RefSeq; NP_217143.1; NC_000962.3.
DR RefSeq; WP_010886153.1; NC_000962.3.
DR AlphaFoldDB; P9WL67; -.
DR SMR; P9WL67; -.
DR STRING; 83332.Rv2627c; -.
DR ESTHER; myctu-RV2627C; 6_AlphaBeta_hydrolase.
DR PaxDb; P9WL67; -.
DR DNASU; 888568; -.
DR GeneID; 888568; -.
DR KEGG; mtu:Rv2627c; -.
DR PATRIC; fig|83332.12.peg.2937; -.
DR TubercuList; Rv2627c; -.
DR eggNOG; COG1073; Bacteria.
DR OMA; WLGYTAN; -.
DR PhylomeDB; P9WL67; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..413
FT /note="Uncharacterized protein Rv2627c"
FT /id="PRO_0000392935"
SQ SEQUENCE 413 AA; 46252 MW; 760893D0508523E0 CRC64;
MASSASDGTH ERSAFRLSPP VLSGAMGPFM HTGLYVAQSW RDYLGQQPDK LPIARPTIAL
AAQAFRDEIV LLGLKARRPV SNHRVFERIS QEVAAGLEFY GNRRWLEKPS GFFAQPPPLT
EVAVRKVKDR RRSFYRIFFD SGFTPHPGEP GSQRWLSYTA NNREYALLLR HPEPRPWLVC
VHGTEMGRAP LDLAVFRAWK LHDELGLNIV MPVLPMHGPR GQGLPKGAVF PGEDVLDDVH
GTAQAVWDIR RLLSWIRSQE EESLIGLNGL SLGGYIASLV ASLEEGLACA ILGVPVADLI
ELLGRHCGLR HKDPRRHTVK MAEPIGRMIS PLSLTPLVPM PGRFIYAGIA DRLVHPREQV
TRLWEHWGKP EIVWYPGGHT GFFQSRPVRR FVQAALEQSG LLDAPRTQRD RSA
