ID   Y2628_MYCTU             Reviewed;         120 AA.
AC   P9WL65; L0TAF6; O06184; Q7D6V2;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Putative uncharacterized protein Rv2628;
GN   OrderedLocusNames=Rv2628;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INDUCTION BY HYPOXIA.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=11416222; DOI=10.1073/pnas.121172498;
RA   Sherman D.R., Voskuil M., Schnappinger D., Liao R., Harrell M.I.,
RA   Schoolnik G.K.;
RT   "Regulation of the Mycobacterium tuberculosis hypoxic response gene
RT   encoding alpha -crystallin.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7534-7539(2001).
RN   [3]
RP   INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, AND DORMANCY REGULON.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=12953092; DOI=10.1084/jem.20030205;
RA   Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA   Sherman D.R., Schoolnik G.K.;
RT   "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT   tuberculosis dormancy program.";
RL   J. Exp. Med. 198:705-713(2003).
RN   [4]
RP   BIOTECHNOLOGY.
RX   PubMed=16931093; DOI=10.1016/j.micinf.2006.03.018;
RA   Leyten E.M., Lin M.Y., Franken K.L., Friggen A.H., Prins C.,
RA   van Meijgaarden K.E., Voskuil M.I., Weldingh K., Andersen P.,
RA   Schoolnik G.K., Arend S.M., Ottenhoff T.H., Klein M.R.;
RT   "Human T-cell responses to 25 novel antigens encoded by genes of the
RT   dormancy regulon of Mycobacterium tuberculosis.";
RL   Microbes Infect. 8:2052-2060(2006).
RN   [5]
RP   INDUCTION BY CARBON MONOXIDE (CO).
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=18474359; DOI=10.1016/j.chom.2008.03.007;
RA   Shiloh M.U., Manzanillo P., Cox J.S.;
RT   "Mycobacterium tuberculosis senses host-derived carbon monoxide during
RT   macrophage infection.";
RL   Cell Host Microbe 3:323-330(2008).
RN   [6]
RP   INDUCTION BY CARBON MONOXIDE (CO), AND DORMANCY REGULON.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=18400743; DOI=10.1074/jbc.m802274200;
RA   Kumar A., Deshane J.S., Crossman D.K., Bolisetty S., Yan B.S., Kramnik I.,
RA   Agarwal A., Steyn A.J.;
RT   "Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium
RT   tuberculosis dormancy regulon.";
RL   J. Biol. Chem. 283:18032-18039(2008).
RN   [7]
RP   BIOTECHNOLOGY.
RX   PubMed=19926735; DOI=10.1183/09031936.00140009;
RA   Goletti D., Butera O., Vanini V., Lauria F.N., Lange C., Franken K.L.,
RA   Angeletti C., Ottenhoff T.H., Girardi E.;
RT   "Response to Rv2628 latency antigen associates with cured tuberculosis and
RT   remote infection.";
RL   Eur. Respir. J. 36:135-142(2010).
CC   -!- INDUCTION: A member of the dormancy regulon. Induced in response to
CC       reduced oxygen tension (hypoxia), low levels of nitric oxide (NO) and
CC       carbon monoxide (CO). It is hoped that this regulon will give insight
CC       into the latent, or dormant phase of infection.
CC       {ECO:0000269|PubMed:11416222, ECO:0000269|PubMed:12953092,
CC       ECO:0000269|PubMed:18400743, ECO:0000269|PubMed:18474359}.
CC   -!- BIOTECHNOLOGY: Has strong T-cell and IFN-gamma inducing capacity in
CC       human tuberculin skin test positive patients, indicating this might be
CC       a good vaccine candidate. {ECO:0000269|PubMed:16931093,
CC       ECO:0000269|PubMed:19926735}.
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DR   EMBL; AL123456; CCP45426.1; -; Genomic_DNA.
DR   PIR; C70573; C70573.
DR   RefSeq; NP_217144.1; NC_000962.3.
DR   RefSeq; WP_003899403.1; NC_000962.3.
DR   AlphaFoldDB; P9WL65; -.
DR   STRING; 83332.Rv2628; -.
DR   PaxDb; P9WL65; -.
DR   DNASU; 888566; -.
DR   GeneID; 888566; -.
DR   KEGG; mtu:Rv2628; -.
DR   PATRIC; fig|83332.111.peg.2932; -.
DR   TubercuList; Rv2628; -.
DR   eggNOG; ENOG5031T8Z; Bacteria.
DR   OMA; MNSPKWM; -.
DR   Proteomes; UP000001584; Chromosome.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..120
FT                   /note="Putative uncharacterized protein Rv2628"
FT                   /id="PRO_0000393358"
SQ   SEQUENCE   120 AA;  13129 MW;  C4AAE642A61B42F0 CRC64;
     MSTQRPRHSG IRAVGPYAWA GRCGRIGRWG VHQEAMMNLA IWHPRKVQSA TIYQVTDRSH
     DGRTARVPGD EITSTVSGWL SELGTQSPLA DELARAVRIG DWPAAYAIGE HLSVEIAVAV