ID   Y2629_MYCTU             Reviewed;         374 AA.
AC   P9WL63; L0TD40; O06183; Q7D6V1;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Uncharacterized protein Rv2629;
GN   OrderedLocusNames=Rv2629;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 187-203 AND 351-362, AND SUGGESTED ANTIBIOTIC
RP   RESISTANCE.
RX   PubMed=17970586; DOI=10.1021/pr070242z;
RA   Wang Q., Yue J., Zhang L., Xu Y., Chen J., Zhang M., Zhu B., Wang H.,
RA   Wang H.;
RT   "A newly identified 191A/C mutation in the Rv2629 gene that was
RT   significantly associated with rifampin resistance in Mycobacterium
RT   tuberculosis.";
RL   J. Proteome Res. 6:4564-4571(2007).
RN   [3]
RP   INDUCTION BY HYPOXIA.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=11416222; DOI=10.1073/pnas.121172498;
RA   Sherman D.R., Voskuil M., Schnappinger D., Liao R., Harrell M.I.,
RA   Schoolnik G.K.;
RT   "Regulation of the Mycobacterium tuberculosis hypoxic response gene
RT   encoding alpha -crystallin.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7534-7539(2001).
RN   [4]
RP   INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, AND DORMANCY REGULON.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=12953092; DOI=10.1084/jem.20030205;
RA   Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA   Sherman D.R., Schoolnik G.K.;
RT   "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT   tuberculosis dormancy program.";
RL   J. Exp. Med. 198:705-713(2003).
RN   [5]
RP   INDUCTION BY ANAEROBISIS, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=S-02293 Harlingen;
RX   PubMed=15528667; DOI=10.1099/mic.0.27284-0;
RA   Starck J., Kallenius G., Marklund B.I., Andersson D.I., Akerlund T.;
RT   "Comparative proteome analysis of Mycobacterium tuberculosis grown under
RT   aerobic and anaerobic conditions.";
RL   Microbiology 150:3821-3829(2004).
RN   [6]
RP   INDUCTION BY CARBON MONOXIDE (CO), AND DORMANCY REGULON.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=18400743; DOI=10.1074/jbc.m802274200;
RA   Kumar A., Deshane J.S., Crossman D.K., Bolisetty S., Yan B.S., Kramnik I.,
RA   Agarwal A., Steyn A.J.;
RT   "Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium
RT   tuberculosis dormancy regulon.";
RL   J. Biol. Chem. 283:18032-18039(2008).
RN   [7]
RP   NOT RESPONSIBLE FOR ANTIBIOTIC RESISTANCE.
RX   PubMed=18550732; DOI=10.1128/jcm.00666-08;
RA   Chakravorty S., Aladegbami B., Motiwala A.S., Dai Y., Safi H.,
RA   Brimacombe M., Helb D., Alland D.;
RT   "Rifampin resistance, Beijing-W clade-single nucleotide polymorphism
RT   cluster group 2 phylogeny, and the Rv2629 191-C allele in Mycobacterium
RT   tuberculosis strains.";
RL   J. Clin. Microbiol. 46:2555-2560(2008).
RN   [8]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- INDUCTION: Induced by anaerobisis (at protein level). A member of the
CC       dormancy regulon. Induced in response to reduced oxygen tension
CC       (hypoxia), low levels of nitric oxide (NO) and carbon monoxide (CO). It
CC       is hoped that this regulon will give insight into the latent, or
CC       dormant phase of infection. {ECO:0000269|PubMed:11416222,
CC       ECO:0000269|PubMed:12953092, ECO:0000269|PubMed:15528667,
CC       ECO:0000269|PubMed:18400743}.
CC   -!- CAUTION: A fairly frequent variant (Ala-64) was originally
CC       (PubMed:17970586) suggested to be responsible for some cases of
CC       rifampicin resistance. This has since been shown not to be true
CC       (PubMed:18550732), although it is a good marker for the Beijing-W
CC       clade/SCG-2 phylogenetic group. {ECO:0000305|PubMed:17970586,
CC       ECO:0000305|PubMed:18550732}.
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DR   EMBL; AL123456; CCP45427.1; -; Genomic_DNA.
DR   PIR; D70573; D70573.
DR   RefSeq; NP_217145.1; NC_000962.3.
DR   RefSeq; WP_003413610.1; NZ_NVQJ01000075.1.
DR   AlphaFoldDB; P9WL63; -.
DR   SMR; P9WL63; -.
DR   STRING; 83332.Rv2629; -.
DR   PaxDb; P9WL63; -.
DR   DNASU; 888588; -.
DR   GeneID; 888588; -.
DR   KEGG; mtu:Rv2629; -.
DR   TubercuList; Rv2629; -.
DR   eggNOG; COG1503; Bacteria.
DR   OMA; WSERHFQ; -.
DR   PhylomeDB; P9WL63; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0001666; P:response to hypoxia; IEP:MTBBASE.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   InterPro; IPR040701; Bact_RF_family2.
DR   InterPro; IPR029064; L30e-like.
DR   Pfam; PF18844; baeRF_family2; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Direct protein sequencing; Reference proteome.
FT   CHAIN           1..374
FT                   /note="Uncharacterized protein Rv2629"
FT                   /id="PRO_0000392936"
FT   COILED          39..66
FT                   /evidence="ECO:0000255"
FT   VARIANT         64
FT                   /note="D -> A (common variant in the Beijing-W clade/SCG-2
FT                   phylogenetic group)"
SQ   SEQUENCE   374 AA;  40840 MW;  2CEEE9456A395BDB CRC64;
     MRSERLRWLV AAEGPFASVY FDDSHDTLDA VERREATWRD VRKHLESRDA KQELIDSLEE
     AVRDSRPAVG QRGRALIATG EQVLVNEHLI GPPPATVIRL SDYPYVVPLI DLEMRRPTYV
     FAAVDHTGAD VKLYQGATIS STKIDGVGYP VHKPVTAGWN GYGDFQHTTE EAIRMNCRAV
     ADHLTRLVDA ADPEVVFVSG EVRSRTDLLS TLPQRVAVRV SQLHAGPRKS ALDEEEIWDL
     TSAEFTRRRY AEITNVAQQF EAEIGRGSGL AAQGLAEVCA ALRDGDVDTL IVGELGEATV
     VTGKARTTVA RDADMLSELG EPVDRVARAD EALPFAAIAV GAALVRDDNR IAPLDGVGAL
     LRYAATNRLG SHRS