ID   Y2637_MYCTU             Reviewed;         218 AA.
AC   P9WP07; L0TA78; P63911; P71936;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Uncharacterized membrane protein Rv2637;
GN   OrderedLocusNames=Rv2637; ORFNames=MTCY441.07;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DedA family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45435.1; -; Genomic_DNA.
DR   PIR; A70964; A70964.
DR   RefSeq; NP_217153.1; NC_000962.3.
DR   RefSeq; WP_003413654.1; NZ_NVQJ01000077.1.
DR   AlphaFoldDB; P9WP07; -.
DR   STRING; 83332.Rv2637; -.
DR   PaxDb; P9WP07; -.
DR   DNASU; 888616; -.
DR   GeneID; 45426642; -.
DR   GeneID; 888616; -.
DR   KEGG; mtu:Rv2637; -.
DR   TubercuList; Rv2637; -.
DR   eggNOG; COG0586; Bacteria.
DR   OMA; WGMWAVF; -.
DR   PhylomeDB; P9WP07; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR032818; DedA.
DR   InterPro; IPR032816; SNARE_assoc.
DR   PANTHER; PTHR30353; PTHR30353; 1.
DR   Pfam; PF09335; SNARE_assoc; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..218
FT                   /note="Uncharacterized membrane protein Rv2637"
FT                   /id="PRO_0000161430"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   218 AA;  23003 MW;  5678D5E0C2513635 CRC64;
     MDVEALLQSI PPLMVYLVVG AVVGIESLGI PLPGEIVLVS AAVLSSHPEL AVNPIGVGGA
     AVIGAVVGDS IGYSIGRRFG LPLFDRLGRR FPKHFGPGHV ALAERLFNRW GVRAVFLGRF
     IALLRIFAGP LAGALKMPYP RFLAANVTGG ICWAGGTTAL VYFAGMAAQH WLERFSWIAL
     VIAVIAGITA AILLRERTSR AIAELEAEHC RKAGTTAA