ID   Y2638_MYCTU             Reviewed;         148 AA.
AC   I6X4W0;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Putative anti-anti-sigma factor Rv2638 {ECO:0000305|PubMed:17411339};
GN   OrderedLocusNames=Rv2638 {ECO:0000312|EMBL:CCP45436.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INTERACTION WITH OPRA/RV0516C.
RX   PubMed=17411339; DOI=10.1371/journal.ppat.0030049;
RA   Greenstein A.E., MacGurn J.A., Baer C.E., Falick A.M., Cox J.S., Alber T.;
RT   "M. tuberculosis Ser/Thr protein kinase D phosphorylates an anti-anti-sigma
RT   factor homolog.";
RL   PLoS Pathog. 3:E49-E49(2007).
RN   [3]
RP   INDUCTION.
RX   PubMed=17485404; DOI=10.2741/2417;
RA   Dhandayuthapani S.;
RT   "Stress response of genes encoding putative stress signaling molecules of
RT   Mycobacterium tuberculosis.";
RL   Front. Biosci. 12:4676-4681(2007).
CC   -!- SUBUNIT: Interacts with unphosphorylated OprA.
CC       {ECO:0000269|PubMed:17411339}.
CC   -!- INDUCTION: Slightly induced towards stationary phase. Induced by heat
CC       and oxidative stresses. {ECO:0000269|PubMed:17485404}.
CC   -!- SIMILARITY: Belongs to the anti-sigma-factor antagonist family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP45436.1; -; Genomic_DNA.
DR   RefSeq; NP_217154.1; NC_000962.3.
DR   RefSeq; WP_003413657.1; NZ_NVQJ01000077.1.
DR   AlphaFoldDB; I6X4W0; -.
DR   SMR; I6X4W0; -.
DR   STRING; 83332.Rv2638; -.
DR   PaxDb; I6X4W0; -.
DR   DNASU; 888156; -.
DR   GeneID; 45426643; -.
DR   GeneID; 888156; -.
DR   KEGG; mtu:Rv2638; -.
DR   PATRIC; fig|83332.111.peg.2942; -.
DR   TubercuList; Rv2638; -.
DR   eggNOG; COG1366; Bacteria.
DR   OMA; GCCAFAV; -.
DR   PhylomeDB; I6X4W0; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0043856; F:anti-sigma factor antagonist activity; IBA:GO_Central.
DR   Gene3D; 3.30.750.24; -; 1.
DR   InterPro; IPR003658; Anti-sigma_ant.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   Pfam; PF01740; STAS; 1.
DR   SUPFAM; SSF52091; SSF52091; 1.
DR   TIGRFAMs; TIGR00377; ant_ant_sig; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Stress response.
FT   CHAIN           1..148
FT                   /note="Putative anti-anti-sigma factor Rv2638"
FT                   /id="PRO_0000451031"
FT   DOMAIN          30..141
FT                   /note="STAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00198"
SQ   SEQUENCE   148 AA;  15420 MW;  C279BC99E1ABACB7 CRC64;
     MGLITTEPRS SPHPLSPRLV HELGDPHSTL RATTDGSGAA LLIHAGGEID GRNEHLWRQL
     VTEAAAGVTA PGPLIVDVTG LDFMGCCAFA ALADEAQRCR CRGIDLRLVS HQPIVARIAE
     AGGLSRVLPI YPTVDTALGK GTAGPARC