Y2650_ARATH
ID Y2650_ARATH Reviewed; 536 AA.
AC Q9SJQ5; Q84TJ1;
DT 21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=CBS domain-containing protein CBSCBSPB2;
GN Name=CBSCBSPB2; OrderedLocusNames=At2g36500; ORFNames=F1O11.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19400948; DOI=10.1186/1471-2164-10-200;
RA Kushwaha H.R., Singh A.K., Sopory S.K., Singla-Pareek S.L., Pareek A.;
RT "Genome wide expression analysis of CBS domain containing proteins in
RT Arabidopsis thaliana (L.) Heynh and Oryza sativa L. reveals their
RT developmental and stress regulation.";
RL BMC Genomics 10:200-200(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC006919; AAD24634.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09264.1; -; Genomic_DNA.
DR EMBL; BT005736; AAO64148.1; -; mRNA.
DR PIR; E84781; E84781.
DR RefSeq; NP_181191.1; NM_129208.4.
DR AlphaFoldDB; Q9SJQ5; -.
DR SMR; Q9SJQ5; -.
DR STRING; 3702.AT2G36500.1; -.
DR iPTMnet; Q9SJQ5; -.
DR PaxDb; Q9SJQ5; -.
DR PRIDE; Q9SJQ5; -.
DR ProteomicsDB; 232418; -.
DR EnsemblPlants; AT2G36500.1; AT2G36500.1; AT2G36500.
DR GeneID; 818225; -.
DR Gramene; AT2G36500.1; AT2G36500.1; AT2G36500.
DR KEGG; ath:AT2G36500; -.
DR Araport; AT2G36500; -.
DR TAIR; locus:2044840; AT2G36500.
DR eggNOG; ENOG502QVK2; Eukaryota.
DR HOGENOM; CLU_009026_3_0_1; -.
DR InParanoid; Q9SJQ5; -.
DR OMA; EMVCVEM; -.
DR OrthoDB; 490251at2759; -.
DR PhylomeDB; Q9SJQ5; -.
DR PRO; PR:Q9SJQ5; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SJQ5; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.10.580.10; -; 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR034896; CBSCBSPB.
DR InterPro; IPR000270; PB1_dom.
DR PANTHER; PTHR13780:SF116; PTHR13780:SF116; 1.
DR Pfam; PF00571; CBS; 4.
DR Pfam; PF00564; PB1; 1.
DR SMART; SM00116; CBS; 4.
DR SMART; SM00666; PB1; 1.
DR SUPFAM; SSF54631; SSF54631; 2.
DR PROSITE; PS51371; CBS; 4.
DR PROSITE; PS51745; PB1; 1.
PE 2: Evidence at transcript level;
KW CBS domain; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..536
FT /note="CBS domain-containing protein CBSCBSPB2"
FT /id="PRO_0000412228"
FT TRANSMEM 509..529
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 66..124
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 132..187
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 228..287
FT /note="CBS 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 295..354
FT /note="CBS 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 406..489
FT /note="PB1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01081"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 127
FT /note="L -> P (in Ref. 3; AAO64148)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 536 AA; 58448 MW; BF78242BCA103685 CRC64;
MTTTPTSSGR RSISSIRRTS SASKKPVLQS EESESGSGSI NENTSKPDSP LAQPVSDGER
TVKKLRLSKA LTINEGTTVF DACRRMAARR VDAVLLTDSS ALLSGIVTDK DIATRVIAEG
LRPEHTLVSK VMTRNPIFVT SDSLAIEALQ KMVQGKFRHL PVVENGEVIA LLDITKCLYD
AISRMEKAAE QGSALATAVE ERHWGSGNFA FIDTLRERMF KPALSTIVTE NTKVALVSAS
DPVFVASKKM RDLRVNSVII AVGNKIHGIL TSKDILMRVV AQNLSPELTL VEKVMTPNPE
CASIETTILD ALHIMHDGKF LHLPVFDKDG FAVACLDVLQ ITHAAISTVE NNSSGAVNDM
ANTMMQKFWD SALALEPPED YETHSDMSAM LINSEGKQSC PSQGLVSSFA FKFEDRKGRV
QRFNSTGESF EELMSVVMQR CEADSGLQIM YQDDEGDKVL ISRDSDLVAA VTFARSLGQK
VLRLHLDFTE TIAPLETIAD LSEGNGGCVW WQTGVLAGAI VLTSIGLFVY LKRSKK
