ID   Y2653_MYCTU             Reviewed;         107 AA.
AC   P9WJ13; L0TAH9; P71950; Q7D6U1;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Toxin Rv2653c;
GN   OrderedLocusNames=Rv2653c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   EXPRESSION IN M.SMEGMATIS, AND FUNCTION AS A TOXIN.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA   Ramage H.R., Connolly L.E., Cox J.S.;
RT   "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT   antitoxin systems: implications for pathogenesis, stress responses, and
RT   evolution.";
RL   PLoS Genet. 5:E1000767-E1000767(2009).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system.
CC       Upon expression in M.smegmatis inhibits colony formation. Its toxic
CC       effect is neutralized by coexpression with cognate antitoxin Rv2654c.
CC       {ECO:0000269|PubMed:20011113}.
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DR   EMBL; AL123456; CCP45451.1; -; Genomic_DNA.
DR   PIR; A70966; A70966.
DR   RefSeq; NP_217169.1; NC_000962.3.
DR   RefSeq; WP_003899414.1; NZ_NVQJ01000079.1.
DR   AlphaFoldDB; P9WJ13; -.
DR   SMR; P9WJ13; -.
DR   STRING; 83332.Rv2653c; -.
DR   PaxDb; P9WJ13; -.
DR   GeneID; 887367; -.
DR   KEGG; mtu:Rv2653c; -.
DR   TubercuList; Rv2653c; -.
DR   OMA; FQGERSP; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0045926; P:negative regulation of growth; IMP:MTBBASE.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..107
FT                   /note="Toxin Rv2653c"
FT                   /id="PRO_0000406887"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   107 AA;  12360 MW;  8E491FB29CB65D56 CRC64;
     MTHKRTKRQP AIAAGLNAPR RNRVGRQHGW PADVPSAEQR RAQRQRDLEA IRRAYAEMVA
     TSHEIDDDTA ELALLSMHLD DEQRRLEAGM KLGWHPYHFP DEPDSKQ