ID   Y2654_MYCTU             Reviewed;          81 AA.
AC   P9WJ11; L0TD62; P71951; Q7D6U0;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Antitoxin Rv2654c;
GN   OrderedLocusNames=Rv2654c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   EXPRESSION IN M.SMEGMATIS, AND FUNCTION AS AN ANTITOXIN.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA   Ramage H.R., Connolly L.E., Cox J.S.;
RT   "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT   antitoxin systems: implications for pathogenesis, stress responses, and
RT   evolution.";
RL   PLoS Genet. 5:E1000767-E1000767(2009).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Upon expression in M.smegmatis neutralizes the effect of cognate toxin
CC       Rv2653c. {ECO:0000269|PubMed:20011113}.
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DR   EMBL; AL123456; CCP45452.1; -; Genomic_DNA.
DR   PIR; B70966; B70966.
DR   RefSeq; NP_217170.1; NC_000962.3.
DR   RefSeq; WP_003899415.1; NZ_NVQJ01000079.1.
DR   AlphaFoldDB; P9WJ11; -.
DR   STRING; 83332.Rv2654c; -.
DR   PaxDb; P9WJ11; -.
DR   DNASU; 888154; -.
DR   GeneID; 888154; -.
DR   KEGG; mtu:Rv2654c; -.
DR   TubercuList; Rv2654c; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0045927; P:positive regulation of growth; IMP:MTBBASE.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..81
FT                   /note="Antitoxin Rv2654c"
FT                   /id="PRO_0000406888"
SQ   SEQUENCE   81 AA;  7698 MW;  86E5882CB1057779 CRC64;
     MSGHALAART LLAAADELVG GPPVEASAAA LAGDAAGAWR TAAVELARAL VRAVAESHGV
     AAVLFAATAA AAAAVDRGDP P