ID   Y2668_MYCTA             Reviewed;         110 AA.
AC   A5U5Z1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=UPF0060 membrane protein MRA_2668 {ECO:0000255|HAMAP-Rule:MF_00010};
GN   OrderedLocusNames=MRA_2668;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00010};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00010}.
CC   -!- SIMILARITY: Belongs to the UPF0060 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00010}.
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DR   EMBL; CP000611; ABQ74441.1; -; Genomic_DNA.
DR   RefSeq; WP_003413663.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5U5Z1; -.
DR   STRING; 419947.MRA_2668; -.
DR   EnsemblBacteria; ABQ74441; ABQ74441; MRA_2668.
DR   GeneID; 45426644; -.
DR   KEGG; mra:MRA_2668; -.
DR   eggNOG; COG1742; Bacteria.
DR   HOGENOM; CLU_117653_0_1_11; -.
DR   OMA; GWLWAVD; -.
DR   OrthoDB; 1991345at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_00010; UPF0060; 1.
DR   InterPro; IPR003844; UPF0060.
DR   PANTHER; PTHR36116; PTHR36116; 1.
DR   Pfam; PF02694; UPF0060; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..110
FT                   /note="UPF0060 membrane protein MRA_2668"
FT                   /id="PRO_1000000763"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00010"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00010"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00010"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00010"
SQ   SEQUENCE   110 AA;  11720 MW;  9F13862B9195EFBB CRC64;
     MVVRSILLFV LAAVAEIGGA WLVWQGVREQ RGWLWAGLGV IALGVYGFFA TLQPDAHFGR
     VLAAYGGVFV AGSLAWGMAL DGFRPDRWDV IGALGCMAGV AVIMYAPRGH