ID   Y266_ARCFU              Reviewed;         276 AA.
AC   O29973;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Uncharacterized transporter AF_0266;
GN   OrderedLocusNames=AF_0266;
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EamA transporter family. {ECO:0000305}.
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DR   EMBL; AE000782; AAB90963.1; -; Genomic_DNA.
DR   PIR; B69283; B69283.
DR   AlphaFoldDB; O29973; -.
DR   SMR; O29973; -.
DR   STRING; 224325.AF_0266; -.
DR   TCDB; 2.A.7.3.28; the drug/metabolite transporter (dmt) superfamily.
DR   EnsemblBacteria; AAB90963; AAB90963; AF_0266.
DR   KEGG; afu:AF_0266; -.
DR   eggNOG; arCOG00271; Archaea.
DR   HOGENOM; CLU_033863_4_1_2; -.
DR   OMA; NTLTWPV; -.
DR   PhylomeDB; O29973; -.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000620; EamA_dom.
DR   Pfam; PF00892; EamA; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..276
FT                   /note="Uncharacterized transporter AF_0266"
FT                   /id="PRO_0000108201"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          12..133
FT                   /note="EamA 1"
FT   DOMAIN          150..274
FT                   /note="EamA 2"
SQ   SEQUENCE   276 AA;  30031 MW;  52BC89357733BE80 CRC64;
     MKKWIVLALT VTFWGLAFTA IKYSVRFLSP IAIASLRFAI ANTLFAVIII LGKRIKWKDL
     PKVFALGIFG VSVYHVFLNL GEVYISSGVA SVVISLAPIF VLILSAIFLR ERITYSKVVG
     IIIAFLGVVV ISEPSYANIY GIALVMVSTV AAAIYTTFGK SLLSKYNPIT LTSNAMVLGS
     IPLYPFLPDS IRSLGGDLNL IGSIVFLGIF STFFGYLGWY YFLEKEEASR ASVFLLAIPV
     VSLLAGNILL AEPLTLRTVA GSGLVLLGIY IVVRKR