ID   Y2684_MYCTU             Reviewed;         429 AA.
AC   P9WPD9; L0TD93; O07186; P0A606;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Uncharacterized transporter Rv2684;
GN   OrderedLocusNames=Rv2684; ORFNames=MTCY05A6.05;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CitM (TC 2.A.11) transporter family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL123456; CCP45482.1; -; Genomic_DNA.
DR   PIR; G70528; G70528.
DR   RefSeq; NP_217200.1; NC_000962.3.
DR   RefSeq; WP_003413894.1; NZ_NVQJ01000017.1.
DR   AlphaFoldDB; P9WPD9; -.
DR   SMR; P9WPD9; -.
DR   STRING; 83332.Rv2684; -.
DR   PaxDb; P9WPD9; -.
DR   DNASU; 888366; -.
DR   GeneID; 888366; -.
DR   KEGG; mtu:Rv2684; -.
DR   TubercuList; Rv2684; -.
DR   eggNOG; COG1055; Bacteria.
DR   OMA; IAMFIDV; -.
DR   PhylomeDB; P9WPD9; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015105; F:arsenite transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR000802; Arsenical_pump_ArsB.
DR   InterPro; IPR004680; Cit_transptr-like_dom.
DR   Pfam; PF03600; CitMHS; 1.
DR   PRINTS; PR00758; ARSENICPUMP.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..429
FT                   /note="Uncharacterized transporter Rv2684"
FT                   /id="PRO_0000172514"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   429 AA;  45188 MW;  F9076F9CAC57B86A CRC64;
     MSVVAVTIFV AAYVLIASDR VNKTMVALTG AAAVVVLPVI TSHDIFYSHD TGIDWDVIFL
     LVGMMIIVGV LRQTGVFEYT AIWAAKRARG SPLRIMILLV LVSALASALL DNVTTVLLIA
     PVTLLVCDRL NINTTSFLMA EVFASNIGGA ATLVGDPPNI IVASRAGLTF NDFMLHLTPL
     VVIVLIALIA VLPRLFGSIT VEADRIADVM ALDEGEAIRD RGLLVKCGAV LVLVFAAFVA
     HPVLHIQPSL VALLGAGMLI VVSGLTRSEY LSSVEWDTLL FFAGLFIMVG ALVKTGVVND
     LARAATQLTG GNIVATAFLI LGVSAPISGI IDNIPYVATM TPLVAELVAV MGGQPSTDTP
     WWALALGADF GGNLTAIGAS ANVVMLGIAR RAGAPISFWE FTRKGAVVTA VSIALAAIYL
     WLRYFVLLH