ID   Y2685_MYCTU             Reviewed;         428 AA.
AC   P9WPD7; L0TD23; O07187;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Uncharacterized transporter Rv2685;
GN   OrderedLocusNames=Rv2685; ORFNames=MTCY05A6.06;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CitM (TC 2.A.11) transporter family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP45483.1; -; Genomic_DNA.
DR   PIR; H70528; H70528.
DR   RefSeq; WP_003899431.1; NZ_NVQJ01000017.1.
DR   RefSeq; YP_177899.1; NC_000962.3.
DR   AlphaFoldDB; P9WPD7; -.
DR   SMR; P9WPD7; -.
DR   STRING; 83332.Rv2685; -.
DR   PaxDb; P9WPD7; -.
DR   DNASU; 888150; -.
DR   GeneID; 888150; -.
DR   KEGG; mtu:Rv2685; -.
DR   TubercuList; Rv2685; -.
DR   eggNOG; COG1055; Bacteria.
DR   OMA; YFMYRNK; -.
DR   PhylomeDB; P9WPD7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015105; F:arsenite transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR000802; Arsenical_pump_ArsB.
DR   InterPro; IPR004680; Cit_transptr-like_dom.
DR   Pfam; PF03600; CitMHS; 1.
DR   PRINTS; PR00758; ARSENICPUMP.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..428
FT                   /note="Uncharacterized transporter Rv2685"
FT                   /id="PRO_0000172515"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        314..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        359..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   428 AA;  45238 MW;  EBB33FB2F62A5C7C CRC64;
     MSIIAITVFV AGYALIASDR VSKTRVALTC AAIMVGAGIV GSDDVFYSHE AGIDWDVIFL
     LLGMMIIVSV LRHTGVFEYV AIWAVKRANA APLRIMILLV LVTALGSALL DNVTTVLLIA
     PVTLLVCDRL GVNSTPFLVA EVFASNVGGA ATLVGDPPNI IIASRAGLTF NDFLIHMAPA
     VLVVMIALIG LLPWLLGSVT AEPDRVADVL SLNEREAIHD RGLLIKCGVV LVLVFAAFIA
     HPVLHIQPSL VALLGAGVLV RFSGLERSDY LSSVEWDTLL FFAGLFVMVG ALVKTGVVEQ
     LARAATELTG GNELLTVGLI LGISAPVSGI IDNIPYVATM TPIVTELVAA MPGHVHPDTF
     WWALALSADF GGNLTAVAAS ANVVMLGIAR RSGTPISFWK FTRKGAVVTA VSLVLSAVYL
     WLRYFVFG