ID   Y268_MYCPN              Reviewed;         117 AA.
AC   P75507;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Putative phosphotransferase enzyme IIB component MPN_268;
DE            EC=2.7.1.-;
DE   AltName: Full=Putative PTS system EIIB component;
GN   OrderedLocusNames=MPN_268; ORFNames=A65_orf117, MP565;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS   pneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC       system (PTS), a major carbohydrate active -transport system, catalyzes
CC       the phosphorylation of incoming sugar substrates concomitant with their
CC       translocation across the cell membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DOMAIN: The EIIB domain is phosphorylated by phospho-EIIA on a
CC       cysteinyl or histidyl residue, depending on the transported sugar.
CC       Then, it transfers the phosphoryl group to the sugar substrate
CC       concomitantly with the sugar uptake processed by the EIIC domain.
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DR   EMBL; U00089; AAB96213.1; -; Genomic_DNA.
DR   PIR; S73891; S73891.
DR   RefSeq; NP_109956.1; NC_000912.1.
DR   RefSeq; WP_010874625.1; NC_000912.1.
DR   AlphaFoldDB; P75507; -.
DR   SMR; P75507; -.
DR   IntAct; P75507; 2.
DR   STRING; 272634.MPN_268; -.
DR   EnsemblBacteria; AAB96213; AAB96213; MPN_268.
DR   GeneID; 66609086; -.
DR   KEGG; mpn:MPN_268; -.
DR   PATRIC; fig|272634.6.peg.287; -.
DR   HOGENOM; CLU_2082212_0_0_14; -.
DR   OMA; WLYWRIK; -.
DR   BioCyc; MPNE272634:G1GJ3-419-MON; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1360.60; -; 1.
DR   InterPro; IPR036878; Glu_permease_IIB.
DR   InterPro; IPR001996; PTS_IIB_1.
DR   SUPFAM; SSF55604; SSF55604; 1.
DR   PROSITE; PS51098; PTS_EIIB_TYPE_1; 1.
PE   3: Inferred from homology;
KW   Membrane; Phosphoprotein; Phosphotransferase system; Reference proteome;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..117
FT                   /note="Putative phosphotransferase enzyme IIB component
FT                   MPN_268"
FT                   /id="PRO_0000210430"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          42..117
FT                   /note="PTS EIIB type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00421"
SQ   SEQUENCE   117 AA;  13281 MW;  1C4D912E2718E3DA CRC64;
     MKVLLWIGYV LSFGLLYLYL VKRAKRAALQ LNNKLVESHT IPFAVRDFIA ACGGRTNFVS
     LRTSPTQLIV SFAKPELVQI AALQKLGIKG INKSQNQYRF VLGNFVNQLK QQIENER