ID   Y268_MYCTU              Reviewed;         169 AA.
AC   P95225; F2GM69; I6WXZ2; Q7DA49;
DT   09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Putative antitoxin Rv0268c;
GN   OrderedLocusNames=Rv0268c; ORFNames=LH57_01465;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RA   Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J.,
RA   Monaco A., King S., Sohrabi A.;
RT   "Phylogenetic analysis of Mycobacterial species using whole genome
RT   sequences.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   DISCUSSION OF POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=25467293; DOI=10.1016/j.tube.2014.10.009;
RA   Ramakrishnan G., Ochoa-Montano B., Raghavender U.S., Mudgal R., Joshi A.G.,
RA   Chandra N.R., Sowdhamini R., Blundell T.L., Srinivasan N.;
RT   "Enriching the annotation of Mycobacterium tuberculosis H37Rv proteome
RT   using remote homology detection approaches: insights into structure and
RT   function.";
RL   Tuberculosis 95:14-25(2015).
CC   -!- FUNCTION: Putative antitoxin component of a type II toxin-antitoxin
CC       (TA) system; however the expected toxin coding sequence is not found
CC       adjacent to this gene. {ECO:0000305|PubMed:25467293,
CC       ECO:0000305|PubMed:9634230}.
CC   -!- SIMILARITY: Belongs to the phD/YefM antitoxin family. {ECO:0000305}.
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DR   EMBL; CP009480; AIR12992.1; -; Genomic_DNA.
DR   EMBL; AL123456; CCP42997.1; -; Genomic_DNA.
DR   RefSeq; NP_214782.1; NC_000962.3.
DR   RefSeq; WP_003401383.1; NC_000962.3.
DR   AlphaFoldDB; P95225; -.
DR   SMR; P95225; -.
DR   STRING; 83332.Rv0268c; -.
DR   PaxDb; P95225; -.
DR   PRIDE; P95225; -.
DR   DNASU; 886647; -.
DR   GeneID; 886647; -.
DR   KEGG; mtu:Rv0268c; -.
DR   PATRIC; fig|83332.111.peg.300; -.
DR   TubercuList; Rv0268c; -.
DR   eggNOG; COG2161; Bacteria.
DR   HOGENOM; CLU_1576748_0_0_11; -.
DR   OMA; RQSNGCT; -.
DR   Proteomes; UP000001584; Chromosome.
DR   InterPro; IPR006442; Antitoxin_Phd/YefM.
DR   InterPro; IPR036165; YefM-like_sf.
DR   Pfam; PF02604; PhdYeFM_antitox; 1.
DR   SUPFAM; SSF143120; SSF143120; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..169
FT                   /note="Putative antitoxin Rv0268c"
FT                   /id="PRO_0000434894"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          120..153
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   169 AA;  19460 MW;  7C809DDE71111738 CRC64;
     MGTRSKSRTR QLKQSNGCTA TTSGASDRRR RARRRTAPAW LREDEWLRHH LPHPPRQLSR
     CLHRRRRSAC HHRYSRRTPK GGLPMTSSLV PISEARAHLS RLVRESADDD VVLMNHGRPA
     AILISAERYE SLMEELEDLR DRLSVHEREH VTMPLDKLGA ELGVDIGRV