ID   Y2715_MYCTU             Reviewed;         341 AA.
AC   P9WNH3; L0TD47; O07214; P0A572; P28176;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Uncharacterized protein Rv2715;
GN   OrderedLocusNames=Rv2715; ORFNames=MTCY05A6.36;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 135-341.
RC   STRAIN=Isolate 50410;
RA   Patki A.H., Dale J.W.;
RL   Submitted (APR-1991) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the DmpD/TodF/XylF esterase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Ref.2 (CAA41963) sequence was wrongly assigned to be a
CC       thymidylate synthase. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA41963.1; Type=Frameshift; Note=Including one that fuses RV2715 and RV2716 into one putative protein.; Evidence={ECO:0000305};
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DR   EMBL; AL123456; CCP45513.1; -; Genomic_DNA.
DR   EMBL; X59273; CAA41963.1; ALT_FRAME; Genomic_DNA.
DR   PIR; F70532; F70532.
DR   RefSeq; NP_217231.1; NC_000962.3.
DR   RefSeq; WP_003900558.1; NZ_NVQJ01000017.1.
DR   AlphaFoldDB; P9WNH3; -.
DR   SMR; P9WNH3; -.
DR   STRING; 83332.Rv2715; -.
DR   ESTHER; myctu-YR15; Epoxide_hydrolase.
DR   PaxDb; P9WNH3; -.
DR   DNASU; 887974; -.
DR   GeneID; 45426702; -.
DR   GeneID; 887974; -.
DR   KEGG; mtu:Rv2715; -.
DR   TubercuList; Rv2715; -.
DR   eggNOG; COG2267; Bacteria.
DR   OMA; LEFRTIH; -.
DR   PhylomeDB; P9WNH3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR000639; Epox_hydrolase-like.
DR   Pfam; PF12697; Abhydrolase_6; 1.
DR   PRINTS; PR00111; ABHYDROLASE.
DR   PRINTS; PR00412; EPOXHYDRLASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..341
FT                   /note="Uncharacterized protein Rv2715"
FT                   /id="PRO_0000207084"
FT   ACT_SITE        111
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        247
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        275
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   341 AA;  36933 MW;  F110BAD9FAA0F67C CRC64;
     MTERKRNLRP VRDVAPPTLQ FRTVHGYRRA FRIAGSGPAI LLIHGIGDNS TTWNGVHAKL
     AQRFTVIAPD LLGHGQSDKP RADYSVAAYA NGMRDLLSVL DIERVTIVGH SLGGGVAMQF
     AYQFPQLVDR LILVSAGGVT KDVNIVFRLA SLPMGSEAMA LLRLPLVLPA VQIAGRIVGK
     AIGTTSLGHD LPNVLRILDD LPEPTASAAF GRTLRAVVDW RGQMVTMLDR CYLTEAIPVQ
     IIWGTKDVVL PVRHAHMAHA AMPGSQLEIF EGSGHFPFHD DPARFIDIVE RFMDTTEPAE
     YDQAALRALL RRGGGEATVT GSADTRVAVL NAIGSNERSA T