ID   Y2723_MYCTU             Reviewed;         397 AA.
AC   P9WG93; L0TAP4; O33228; P0A614;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Uncharacterized membrane protein Rv2723;
GN   OrderedLocusNames=Rv2723; ORFNames=MTCY154.03;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TerC family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45521.1; -; Genomic_DNA.
DR   PIR; B70505; B70505.
DR   RefSeq; NP_217239.1; NC_000962.3.
DR   RefSeq; WP_003413979.1; NZ_NVQJ01000017.1.
DR   AlphaFoldDB; P9WG93; -.
DR   STRING; 83332.Rv2723; -.
DR   PaxDb; P9WG93; -.
DR   DNASU; 887768; -.
DR   GeneID; 887768; -.
DR   KEGG; mtu:Rv2723; -.
DR   TubercuList; Rv2723; -.
DR   eggNOG; COG0861; Bacteria.
DR   OMA; EALHDNN; -.
DR   PhylomeDB; P9WG93; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005496; Integral_membrane_TerC.
DR   InterPro; IPR022369; Integral_membrane_TerC_rswitch.
DR   PANTHER; PTHR30238:SF0; PTHR30238:SF0; 1.
DR   Pfam; PF03741; TerC; 1.
DR   TIGRFAMs; TIGR03718; R_switched_Alx; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..397
FT                   /note="Uncharacterized membrane protein Rv2723"
FT                   /id="PRO_0000103421"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   397 AA;  43679 MW;  E85CCFDD414B4C3E CRC64;
     MGASGLVWTL TIVLIAGLML VDYVLHVRKT HVPTLRQAVI QSATFVGIAI LFGIAVVVFG
     GSELAVEYFA CYLTDEALSV DNLFVFLVII SSFGVPRLAQ QKVLLFGIAF ALVTRTGFIF
     VGAALIENFN SAFYLFGLVL LVMAGNLARP TGLESRDAET LKRSVIIRLA DRFLRTSQDY
     NGDRLFTVSN NKRMMTPLLL VMIAVGGTDI LFAFDSIPAL FGLTQNVYLV FAATAFSLLG
     LRQLYFLIDG LLDRLVYLSY GLAVILGFIG VKLMLEALHD NKIPFINGGK PVPTVEVSTT
     QSLTVIIIVL LITTAASFWS ARGRAQNAMA RARRYATAYL DLHYETESAE RDKIFTALLA
     AERQINTLPT KYRMQPGQDD DLMTLLCRAH AARDAHM