Y2729_BURPS
ID Y2729_BURPS Reviewed; 407 AA.
AC Q93SM8; Q63RE3;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Uncharacterized MFS-type transporter BPSL2729 {ECO:0000255|HAMAP-Rule:MF_01118};
GN OrderedLocusNames=BPSL2729;
OS Burkholderia pseudomallei (strain K96243).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; pseudomallei group.
OX NCBI_TaxID=272560;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K96243;
RX PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M.,
RA Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L., Bentley S.D.,
RA Sebaihia M., Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A.,
RA Brown N.F., Challis G.L., Cherevach I., Chillingworth T., Cronin A.,
RA Crossett B., Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z.,
RA Hauser H., Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S.,
RA Price C., Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M.,
RA Simmonds M., Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M.,
RA Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT "Genomic plasticity of the causative agent of melioidosis, Burkholderia
RT pseudomallei.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-407.
RC STRAIN=G9313;
RA Steiner B., Smole S., Bowen M., Morrill W., Meyer R.;
RT "Random sequencing of Burkholderia pseudomallei strain G9313 for the
RT development of a clinical PCR detection method.";
RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01118}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01118}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. YhhS family.
CC {ECO:0000255|HAMAP-Rule:MF_01118}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK40362.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; BX571965; CAH36737.1; -; Genomic_DNA.
DR EMBL; AY032866; AAK40362.1; ALT_FRAME; Genomic_DNA.
DR RefSeq; WP_004185668.1; NZ_CP009538.1.
DR RefSeq; YP_109325.1; NC_006350.1.
DR AlphaFoldDB; Q93SM8; -.
DR SMR; Q93SM8; -.
DR STRING; 272560.BPSL2729; -.
DR EnsemblBacteria; CAH36737; CAH36737; BPSL2729.
DR GeneID; 56594948; -.
DR KEGG; bps:BPSL2729; -.
DR PATRIC; fig|272560.51.peg.2596; -.
DR eggNOG; COG2814; Bacteria.
DR OMA; CAFVGAR; -.
DR Proteomes; UP000000605; Chromosome 1.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1250.20; -; 1.
DR HAMAP; MF_01118; MFS_YhhS; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR023008; MFS_YhhS-like.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..407
FT /note="Uncharacterized MFS-type transporter BPSL2729"
FT /id="PRO_0000087813"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01118"
FT CONFLICT 129
FT /note="I -> V (in Ref. 2; AAK40362)"
FT /evidence="ECO:0000305"
FT CONFLICT 176..181
FT /note="ISHALI -> DLARAD (in Ref. 2; AAK40362)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 407 AA; 41264 MW; B1A55D8A2862993E CRC64;
MSADSADSVP SPRSAFATTL QIVSVVSFTF ICYLTIGLPL AVLPGFVHDE LGFSAIVAGA
AISVQYFATL ASRPLAGRCA DTLGPKRTVL RGLAACGASG ALLLSAFAFA RWPAASIGLL
VASRLVLGIG ESLVGTGAIL WGIGRVGTAH NARVISWNGI ATYGALAIGA PVGVAISHAL
IPAVLGMLVI ALAALGYYLA RLITPVPLVH GERMSYASVL TRVLPHGLGL ALGSAGFGSI
ATFITLYYAA RHWPNAALSL TVFGTLFIGA RLLFANTIKT HGGFRVAIVS FAFECAGLLM
LWLAPVPHVA LVGAALTGFG FALIFPALGV EAVALVPPAS RGAALSAYSV FLDLSLGITG
PLAGYVAGAF GYPQVFLCAA VAAAAGVALS TVLYQRQARL SGSGAAA
