ID   Y273_STRP8              Reviewed;         256 AA.
AC   Q8P2M5;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Probable ABC transporter ATP-binding protein spyM18_0273;
GN   OrderedLocusNames=spyM18_0273;
OS   Streptococcus pyogenes serotype M18 (strain MGAS8232).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=186103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS8232;
RX   PubMed=11917108; DOI=10.1073/pnas.062526099;
RA   Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S.,
RA   Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D.,
RA   Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A.,
RA   Veasy L.G., Musser J.M.;
RT   "Genome sequence and comparative microarray analysis of serotype M18 group
RT   A Streptococcus strains associated with acute rheumatic fever outbreaks.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Ycf16 family.
CC       {ECO:0000305}.
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DR   EMBL; AE009949; AAL97049.1; -; Genomic_DNA.
DR   RefSeq; WP_011017330.1; NC_003485.1.
DR   AlphaFoldDB; Q8P2M5; -.
DR   SMR; Q8P2M5; -.
DR   KEGG; spm:spyM18_0273; -.
DR   HOGENOM; CLU_000604_48_1_9; -.
DR   OMA; MAMLEPK; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProt.
DR   CDD; cd03217; ABC_FeS_Assembly; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR010230; FeS-cluster_ATPase_SufC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR43204; PTHR43204; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01978; sufC; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding; Transport.
FT   CHAIN           1..256
FT                   /note="Probable ABC transporter ATP-binding protein
FT                   spyM18_0273"
FT                   /id="PRO_0000093215"
FT   DOMAIN          4..246
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         36..43
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   256 AA;  28168 MW;  C8E635B9CBE93746 CRC64;
     MSILEINNLH VSIEGKEILK GVNLTLKTGE VAAIMGPNGT GKSTLSAAIM GNPNYEVTQG
     QILLDGVNIL DLEVDERARL GLFLAMQYPS EIPGITNAEF MRAAMNADKA DEDKISVRDF
     ITKLDEKMAL LGMKEEMAER YLNEGFSGGE KKRNEILQLL MLEPKFALLD EIDSGLDIDA
     LKVVSKGVNE MRGKDFGAMI ITHYQRLLNY ITPDLVHVMM DGRIVLSGDA ALATRLEKEG
     YAGIAQDLGI EYKEES