ID   Y2757_MYCTA             Reviewed;         450 AA.
AC   A5U683;
DT   22-JUL-2015, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Uncharacterized protein MRA_2757;
GN   OrderedLocusNames=MRA_2757;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND PZA-BINDING.
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=21835980; DOI=10.1126/science.1208813;
RA   Shi W., Zhang X., Jiang X., Yuan H., Lee J.S., Barry C.E. III, Wang H.,
RA   Zhang W., Zhang Y.;
RT   "Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis.";
RL   Science 333:1630-1632(2011).
CC   -!- MISCELLANEOUS: Binds pyrazinoic acid (POA), the active form of the
CC       first-line anti-tuberculosis prodrug pyrazinamide (PZA).
CC       {ECO:0000269|PubMed:21835980}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000611; ABQ74533.1; -; Genomic_DNA.
DR   RefSeq; WP_003413997.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5U683; -.
DR   SMR; A5U683; -.
DR   STRING; 419947.MRA_2757; -.
DR   EnsemblBacteria; ABQ74533; ABQ74533; MRA_2757.
DR   GeneID; 45426718; -.
DR   KEGG; mra:MRA_2757; -.
DR   eggNOG; COG1196; Bacteria.
DR   HOGENOM; CLU_024630_1_0_11; -.
DR   OMA; DELWHRF; -.
DR   OrthoDB; 1230240at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   InterPro; IPR007139; DUF349.
DR   Pfam; PF03993; DUF349; 3.
PE   1: Evidence at protein level;
KW   Coiled coil.
FT   CHAIN           1..450
FT                   /note="Uncharacterized protein MRA_2757"
FT                   /id="PRO_0000433596"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          387..450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          163..192
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..45
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        387..433
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   450 AA;  49796 MW;  8DE8165AA6FA9BA2 CRC64;
     MTADEPRSDD SSGSAPQPAA TPVPRPGPRP GPRPVPRPTS YPVGAHPPSD PHRFGRIDDD
     GTVWLVSASG ERIVGSWQAG DPEAAFAHFG RRFDDLSTEI MLMDERLASG TGDARKIKAH
     AIALAETLPT ACVLGDVDAL ADRLTSIRDR AEVIAAADRS RREEHRAAQT ARKEALAAEA
     EELAANATQW KVAGDRLRAI LDEWKTISGV DRKVDDALWK RYSTARDTFN RRRGSHFAEL
     DRERSGVRQS KERLCERAEE LSESTDWTAT SAEFRKLLAD WKAAGRASKD VDDALWRRFK
     AAQDSFFTAR NAATAEKEAE LRANADAKEA LLAEAERLDT TNHEAARAAL RSIAEKWDAI
     GKVSRERAAE LERRLRAVEK KVREAGEADW SDPQARARAE QFRARAEQFE HQAEKAAAAG
     RTKEADEAKA NAEQWRQWAE AAADALTRRP