ID   Y2781_YERPE             Reviewed;         182 AA.
AC   Q8ZD12; Q0WDB0;
DT   10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Uncharacterized Nudix hydrolase YPO2781/y1614/YP_2383;
DE            EC=3.6.-.-;
GN   OrderedLocusNames=YPO2781, y1614, YP_2383;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family. {ECO:0000305}.
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DR   EMBL; AL590842; CAL21400.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM85183.1; -; Genomic_DNA.
DR   EMBL; AE017042; AAS62588.1; -; Genomic_DNA.
DR   PIR; AE0339; AE0339.
DR   RefSeq; WP_002209742.1; NZ_WUCM01000012.1.
DR   RefSeq; YP_002347728.1; NC_003143.1.
DR   AlphaFoldDB; Q8ZD12; -.
DR   SMR; Q8ZD12; -.
DR   IntAct; Q8ZD12; 4.
DR   STRING; 214092.YPO2781; -.
DR   PaxDb; Q8ZD12; -.
DR   DNASU; 1146561; -.
DR   EnsemblBacteria; AAM85183; AAM85183; y1614.
DR   EnsemblBacteria; AAS62588; AAS62588; YP_2383.
DR   GeneID; 66844976; -.
DR   KEGG; ype:YPO2781; -.
DR   KEGG; ypk:y1614; -.
DR   KEGG; ypm:YP_2383; -.
DR   PATRIC; fig|214092.21.peg.3228; -.
DR   eggNOG; COG1443; Bacteria.
DR   HOGENOM; CLU_060552_3_0_6; -.
DR   OMA; PGYWDVA; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   InterPro; IPR000086; NUDIX_hydrolase_dom.
DR   InterPro; IPR024195; NUDIX_hydrolase_YfcD_pred.
DR   Pfam; PF00293; NUDIX; 1.
DR   PIRSF; PIRSF017340; Nudix_hydro; 1.
DR   SUPFAM; SSF55811; SSF55811; 1.
DR   PROSITE; PS51462; NUDIX; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Magnesium; Metal-binding; Reference proteome.
FT   CHAIN           1..182
FT                   /note="Uncharacterized Nudix hydrolase
FT                   YPO2781/y1614/YP_2383"
FT                   /id="PRO_0000057088"
FT   DOMAIN          36..164
FT                   /note="Nudix hydrolase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00794"
FT   MOTIF           73..95
FT                   /note="Nudix box"
FT   BINDING         89
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         93
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   182 AA;  20654 MW;  517C3E32876DDC90 CRC64;
     MVEQNPAAVI EWVDIVDEQN NVIAQSSRQQ MRAQRLRHRA TYIVVHDGMG KILVQRRTES
     KDFHPGKLDA TAGGVVQSGE NYLESARREA EEELGIAGVP FAEHGQFYFE EECCRVWGAL
     FSCVSHGPFA LQPEEIDEVC WMVPEEITAR CDEFTPDSLK ALSLWLTRNN EQDYGKITPR
     EA