Y2801_DICDI
ID Y2801_DICDI Reviewed; 3080 AA.
AC Q54S52;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 23-FEB-2022, entry version 72.
DE RecName: Full=Protein PIEZO homolog;
GN ORFNames=DDB_G0282801;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PIEZO (TC 1.A.75) family. {ECO:0000305}.
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DR EMBL; AAFI02000047; EAL66260.1; -; Genomic_DNA.
DR RefSeq; XP_640187.1; XM_635095.1.
DR STRING; 44689.DDB0233999; -.
DR PaxDb; Q54S52; -.
DR PRIDE; Q54S52; -.
DR EnsemblProtists; EAL66260; EAL66260; DDB_G0282801.
DR GeneID; 8623728; -.
DR KEGG; ddi:DDB_G0282801; -.
DR dictyBase; DDB_G0282801; pzoA.
DR eggNOG; KOG1893; Eukaryota.
DR HOGENOM; CLU_225851_0_0_1; -.
DR InParanoid; Q54S52; -.
DR OMA; CFTVQAD; -.
DR PRO; PR:Q54S52; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR GO; GO:0008381; F:mechanosensitive ion channel activity; IBA:GO_Central.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IMP:dictyBase.
DR GO; GO:0050982; P:detection of mechanical stimulus; IMP:dictyBase.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR InterPro; IPR027272; Piezo.
DR InterPro; IPR031334; Piezo_RRas-bd_dom.
DR PANTHER; PTHR13167; PTHR13167; 1.
DR Pfam; PF12166; Piezo_RRas_bdg; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..3080
FT /note="Protein PIEZO homolog"
FT /id="PRO_0000393725"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 438..458
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 672..692
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 700..720
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 740..760
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 827..847
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 849..869
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 872..892
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 928..948
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1036..1056
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1067..1087
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1281..1301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1316..1336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1360..1380
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1472..1492
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1519..1539
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1619..1639
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 2078..2098
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 2112..2132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 2199..2219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 2427..2447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 2457..2477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 2500..2520
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 2530..2550
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 2553..2573
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 2671..2691
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 2955..2975
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 469..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1158..1185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1199..1253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1704..1812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1873..1899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1958..2032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2277..2367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2835..2863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3054..3080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1199..1251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1715..1812
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 312
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 339
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 434
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 514
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 567
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 606
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 795
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 918
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 992
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1191
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1240
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1251
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1424
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1440
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1559
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1589
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1731
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1734
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1763
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1768
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1771
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1779
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1807
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1864
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2027
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2148
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2285
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2478
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2762
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2790
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2837
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2840
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2848
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2858
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2908
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2913
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2935
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3057
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 3080 AA; 356339 MW; 156064597EB0C809 CRC64;
MIGYFFVSLI YPFSLICSSV FRSNVVSYIY FIFFLLSILC LPHKSLILKN KISKTLPIIT
LVLSMFSLIL QLLVNVVKVF QEQDELSVNI LTAFGFYKYN SFWIVFRNVL PDVIVFVISL
FTIILWFKNL VYPASINIKD SLKKTTSLNN VDQILNSPYV HGGSGNFNSG SNNNNNNNNI
VYRPAGRGLT GFSFLMLTLS SISYPSIINV IYFVFTILII LLLASKLSIH KVMLKCYPIL
LITSLCHLLF VYLNQIEYFY MKYTVFKEQK WYGVLNYTEW DVTYWPLVIG YITVLLLYIS
TCILFRKQQL FNRTKPRYKQ KLDKLGIMSD SNNNNNNNNK SRTTKLAIIF SKHGWTICCS
QILVVCFFLT ASVASAILLA SGLICTLLPL KVFKKVIYII LLYFLVFISA QYIFNIPFSY
SETDLQSYGL FSFNNSKWLY IGVQIVVSLT LSLYCFYSDI KDDDLGTIKK DQQSQQSQPQ
PQQQQQQQQS SQNNQIQQSP LQYQQPLPPT PISNKSLPSS PMSTKSTTVH IQNNNNGGGG
GIIRPRKPLP PVPLGMIGKS SMAMTSNSSF GSNKPLNYIQ QQQLQLQQQK VIGYQTSASI
NQLDINDSFS IAFPSLMLLT SGIGKGYDTF RGKYGGTFSK ITSSLKAIAE ITFLAIIGQS
YRLALVGLFF CGLTSINLLN AGYMLFFIVF VISESLASRF WMCLIIYAQM VLLTLYIWQL
SWISSYENDL TVLIGMTNYY GSPLWVGLIW HIIIITFSII QWNVNKLYQR GLFSSSSSSS
SSSNNNQNNN QNNQNNSYED KFKNIPNFLL VFGDFIYRSV QQLSLPFCYL VIVIVSIFTK
ISLINIVYMA TVFLCLLIHH ISANGSIHIK RFWIIIILSQ GVVLVARYIM QFNQVSHWLN
SIFPKSNYIS LSDIGLRNYS SSDRFIELFG CSSILVVCVF QLTVFFSIGQ QQQQQQQQQQ
QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ LNTSNNNNQN NNNLIIKKYT FFDSLLYIVK
RICYLHGPKF VLWMVFAISI AEYNFFNFIY LIMIVISMSF KKGTYRIGSF LLFYSQLWVL
TQLAALLPTV QSFNSDKFFM DWVGLRQPNV STPWDAVKLN LAIILVISIQ QTSYWWNKEI
QNEKLEIKKK KQLKKQQQQQ RKLEEHEEEY EEEEDQFGNK KNNDKLSLLS NDSIEIILDD
GNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN QSNNENNENN NNSKKENLKK
RLFWYISNFY ELYGLECVFL VLAFALFWRL NILGMIYLII IAVGLNIDKR NLHKLIYVSA
LLAPTILIQY LLILVVPTKE NSYPWLDHPF FLNHKTIDNL LLLSIPDRYV LVIDFLVLFF
SMLLFKQRNG YYLYKDFELH QQQQLNQQLN QQQHDSLKSI ASSNSSSQKP LHPKNFFKFN
SSIDGGDDDF TKEPRSWSNE LRYMIIRYSS QVILIVIFLA GTAECDILSC FYVFFSVYVL
FSGNAHSRKW SYLWKSLHIY NWLVLMAQII FQVAVILYFQ FKFNSNQMFE GHNHNHNHNH
SSSSSSSSSG SIIDILSSQS SAIGIGGGNS SGSDSSYEVI ENSLPTELYN IAVVFGFKIE
TGPLSISTIS DVIIMVLLAY QKMIFQSRDF HILEEHLKAK RDLNYETARE FYKIRRNARI
EQLNSIQDKI TQRRSRLQHL KLKRINRRKN RHNHYYNNNP NNNYNNNNNN NNSNSSNSNN
NNNDDDSNEP LSLGDNSFVP PKNTTNQNAT NSTYSPFANS TMHMPPYENN NNNNNNNNNF
NNNPLSNSSS TVSSFGVIEK PLEKKNWVKI YLNKILDWLD PLPDILIENY KKQQLQQQQK
LEMNQSLLFG DQLQQEQQQQ QEQQQQLNPQ QQQSQSSKEL PPILEQFEHN DDDFEISLNQ
APGDYRNSIF IDSEQMRNAM QQMEQRRQQR LQQSIDASQL LQQQQQQQQA SSSNTNTNSN
NNNYNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NEIPKPNQTS SSTITLEPIE
DEEEFLYKEK TQYFKRIIRG FSRIARDESK WLVFMACIAN GVFYNSIISL VYLLAVFLYG
RLFESPRPSK NFWRFMIGYS SLIICLKYVF QIPKNYYNCN ENYHNSNNGT ILMTSTSVYN
TNNNINNNNQ LNNNENYEWW QCPNTLLSEQ NLLLTLPYVF GLYIIDGHFI SGAFWDLAIL
LCCLWHRHVY RSKGLWNFQE KDFYVDQKQQ SPLNLFNLDQ QHFDQQQIDQ IQNQQDLNNS
PISLNSSNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNND QTLIDINNNN NNNNNNNNNN
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNI IIDQILVDCS NEYDEEDQQQ FNEFYDEEFD
DRNEQEKEND EQEIQVIKKS SKSIAKIIIY PFKWLFVSII EYVWLAIRTD EKPGRDYYMP
LLFTDFACLF FLVIFPQNFT GIPSSDIAEF LEQNVIPRQY IVILLAQFGV IILDRIIYLY
KSVKAKFVLQ IVLTVLYHVF LFFYFPDLIV KPFSFGYTWP LVVFYLMKCI YLYYSALQIC
YGYPILSQNR FLMDGYSDFH NIGYALYKAI PFVYELRTLL DWIATDTTML FYDWLKFEDL
YSTIFSVKCR LEWIKRQGRQ KGHKQPKFEK FVTGVTFFIG LVILLWFPLI ILSSGLPGSN
IEPVNNIQIE VSVVGWNPFL KINQDLSLES GDGDSTMDQN SFNNLKEDYS FLTTDDRQGI
QNISINTFSE EIWNLSPPAK AQLINYLLTN TSLQIEVSYT LTRSGGVNSV IVGSNSVQLK
PDQELNFYNI LTRVQSNNSN NSNNPNENSS SGSDDNNNNS NNNIGSNSFI VEGLFYKFIK
LPGVSGNPIY PTDNNGNVLA LDALFTMNST NFNNSNQPPQ YFWQVNAYDS TKTYNISTLE
SIQFYTISSK LPNGITSTLV SAGIIGLYVS VVLSVGRFLR LSITQISIKI QLENLDSCDE
ILKMIDDVFI AREYGDLVLE EELYHELIQV FRQPQLLYSL TTFKNNQLNL PTTPTINSTL
NNQNNQNNNN NNNNNHEKIN
