Y281_HAEIN
ID Y281_HAEIN Reviewed; 438 AA.
AC P44610;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Putative metabolite transport protein HI_0281;
GN OrderedLocusNames=HI_0281;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; L42023; AAC21944.1; -; Genomic_DNA.
DR PIR; A64147; A64147.
DR RefSeq; NP_438449.1; NC_000907.1.
DR RefSeq; WP_005660680.1; NC_000907.1.
DR AlphaFoldDB; P44610; -.
DR SMR; P44610; -.
DR STRING; 71421.HI_0281; -.
DR EnsemblBacteria; AAC21944; AAC21944; HI_0281.
DR KEGG; hin:HI_0281; -.
DR PATRIC; fig|71421.8.peg.297; -.
DR eggNOG; COG0477; Bacteria.
DR HOGENOM; CLU_001265_39_5_6; -.
DR OMA; SWVGGYV; -.
DR PhylomeDB; P44610; -.
DR BioCyc; HINF71421:G1GJ1-300-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004736; MHS_symport.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00883; 2A0106; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..438
FT /note="Putative metabolite transport protein HI_0281"
FT /id="PRO_0000050488"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..52
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..115
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..181
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..286
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..336
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 337..342
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 343..363
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 364..377
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 399..405
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..426
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 427..438
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 438 AA; 46900 MW; D3A01A3EAF9DFCAB CRC64;
MSTQLRNNPM KVALASMVGT AIEFFDYYIY AAAAVLVFNT QFFHSDDPLS NDLLSLSTLA
LAFFARPIGS ALFGHFGDKI GRKKTLVASL VLMGGSTVVI GLLPNYAQIG IWAPILLCVC
RVGQGIGLGG EWGGAALVAT ENAPEGKRAW YGTFPQLGAP IGLFVANGTF FLVSYLLGHN
ALVEWAWRIP FVSSILLVAV GLYVRLTLHE SHVFVEAEQK GKKLNAPVSV VFTKHLKPMV
IGTFIMVATY SLFYIMTAFA QAYSRTAPKL SEAGYALGLG IPANTFTGLL LISAIVFGIF
ISISGFYADK IGRRKWLIWV TIAIGVLGLA MPLFLENGTP VSVFAFLVIG MAIMGMTFGP
MAALLPELFP TEVRYSGASL AYNLASIIGA TIAAMISLKI NASFGVMGVG IYLAINALMT
FLALLASKET KNVDLTEI
