Y2829_DICDI
ID Y2829_DICDI Reviewed; 530 AA.
AC Q86L54; Q558Y4;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=TNF receptor-associated factor family protein DDB_G0272829;
GN ORFNames=DDB_G0272829;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probable adapter protein and signal transducer that links
CC members of the tumor necrosis factor receptor family to different
CC signaling pathways by association with the receptor cytoplasmic domain
CC and kinases. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000008; EAL71052.1; -; Genomic_DNA.
DR RefSeq; XP_644932.1; XM_639840.1.
DR AlphaFoldDB; Q86L54; -.
DR STRING; 44689.DDB0168944; -.
DR PaxDb; Q86L54; -.
DR EnsemblProtists; EAL71052; EAL71052; DDB_G0272829.
DR GeneID; 8618611; -.
DR KEGG; ddi:DDB_G0272829; -.
DR dictyBase; DDB_G0272829; -.
DR HOGENOM; CLU_514306_0_0_1; -.
DR InParanoid; Q86L54; -.
DR OMA; CEYSEIV; -.
DR PhylomeDB; Q86L54; -.
DR Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR PRO; PR:Q86L54; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 4.
DR InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; PTHR10131; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50145; ZF_TRAF; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..530
FT /note="TNF receptor-associated factor family protein
FT DDB_G0272829"
FT /id="PRO_0000393768"
FT ZN_FING 35..81
FT /note="RING-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 134..188
FT /note="TRAF-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT ZN_FING 189..246
FT /note="TRAF-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT REGION 242..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 361..422
FT /evidence="ECO:0000255"
FT COMPBIAS 391..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 530 AA; 61564 MW; EE75E9DB05C024BC CRC64;
MKLGRDIPIY KLIIIKNESI ENNLKEISFS DNFKCQICEG LLISSLIPNR MKALQCINGH
CFCLTCWESI LEIKSECPTC RIQIQSMNTL SNNLFIIKSI SESIKIHCPN YLNFDNSNNF
NGCKEIITID EIDRHESKCE FRFIKCSINN QCNEIIRFNE RDKHESQCDF IIQKCTHCDE
SVQMKQMQGH ILFECLKVLI TCQHCSLQFT RLKLQNHIEN HCKEIKIECP FKSLKIIYNN
NNNDNDNNDS DENNSNQSLS SSSLSSSIIP LSPCNELMKR SELSKHFIRN HQYHNELVSI
VLKKQENKIK KLETIIQQNN VNQNFEISII KHSNSLTRDS FYKENKKKDK LIQDLMKRVL
ILEHQQQQNQ IQNQIQNQIQ KLSNKSIFTT TTTTTSTSDK NNNNNNNNNN NNNNNNEDEE
DDDNIKNNDN QGNLKSLREM FNTISNFKDD ENEQQQIQQQ QQLPFTSFGP LSVQQQNNPT
KQFNQLSQPQ TQPQSQSQSQ SLFGEWSPIT INQNQNTPSN PFSIFSGTSL
