ID   Y2829_STAA8             Reviewed;         223 AA.
AC   Q2FVA4;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Putative NAD(P)H nitroreductase SAOUHSC_02829;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=SAOUHSC_02829;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the nitroreductase family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD31831.1; -; Genomic_DNA.
DR   RefSeq; WP_000069101.1; NZ_LS483365.1.
DR   RefSeq; YP_501288.1; NC_007795.1.
DR   PDB; 7JH4; X-ray; 2.00 A; A/B/C/D/E=1-223.
DR   PDBsum; 7JH4; -.
DR   AlphaFoldDB; Q2FVA4; -.
DR   SMR; Q2FVA4; -.
DR   STRING; 1280.SAXN108_2772; -.
DR   EnsemblBacteria; ABD31831; ABD31831; SAOUHSC_02829.
DR   GeneID; 3921268; -.
DR   KEGG; sao:SAOUHSC_02829; -.
DR   PATRIC; fig|93061.5.peg.2559; -.
DR   eggNOG; COG0778; Bacteria.
DR   HOGENOM; CLU_070764_4_1_9; -.
DR   OMA; PWHFVVA; -.
DR   PRO; PR:Q2FVA4; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0018545; F:NAD(P)H nitroreductase activity; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0046256; P:2,4,6-trinitrotoluene catabolic process; IBA:GO_Central.
DR   CDD; cd02149; NfsB-like; 1.
DR   Gene3D; 3.40.109.10; -; 1.
DR   InterPro; IPR033878; NfsB-like.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   Pfam; PF00881; Nitroreductase; 1.
DR   SUPFAM; SSF55469; SSF55469; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Flavoprotein; FMN; NAD; NADP; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..223
FT                   /note="Putative NAD(P)H nitroreductase SAOUHSC_02829"
FT                   /id="PRO_0000277537"
FT   HELIX           4..14
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   HELIX           29..40
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   HELIX           45..47
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   STRAND          51..56
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   HELIX           59..67
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   HELIX           70..72
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   HELIX           73..78
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   STRAND          80..89
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   HELIX           96..104
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   HELIX           110..112
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   HELIX           113..126
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   HELIX           129..131
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   HELIX           133..157
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   STRAND          161..165
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   HELIX           170..179
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   TURN            185..187
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   STRAND          188..197
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   STRAND          199..201
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   HELIX           212..215
FT                   /evidence="ECO:0007829|PDB:7JH4"
FT   STRAND          216..220
FT                   /evidence="ECO:0007829|PDB:7JH4"
SQ   SEQUENCE   223 AA;  25389 MW;  86CFC18027E327C6 CRC64;
     MSNMNQTIMD AFHFRHATKQ FDPQKKVSKE DFETILESGR LSPSSLGLEP WKFVVIQDQA
     LRDELKAHSW GAAKQLDTAS HFVLIFARKN VTSRSPYVQH MLRDIKKYEA QTIPAVEQKF
     DAFQADFHIS DNDQALYDWS SKQTYIALGN MMTTAALLGI DSCPMEGFSL DTVTDILANK
     GILDTEQFGL SVMVAFGYRQ QEPPKNKTRQ AYEDVIEWVG PKE