ID   Y282_TREPA              Reviewed;         239 AA.
AC   O83306;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=TPR repeat-containing protein TP_0282;
GN   OrderedLocusNames=TP_0282;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AE000520; AAC65279.1; -; Genomic_DNA.
DR   PIR; E71343; E71343.
DR   RefSeq; WP_010881731.1; NC_021490.2.
DR   AlphaFoldDB; O83306; -.
DR   SMR; O83306; -.
DR   IntAct; O83306; 7.
DR   STRING; 243276.TPANIC_0282; -.
DR   EnsemblBacteria; AAC65279; AAC65279; TP_0282.
DR   GeneID; 57878823; -.
DR   KEGG; tpa:TP_0282; -.
DR   eggNOG; COG1729; Bacteria.
DR   HOGENOM; CLU_105450_0_0_12; -.
DR   OMA; DDASIWF; -.
DR   OrthoDB; 1444515at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Repeat; TPR repeat;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..239
FT                   /note="TPR repeat-containing protein TP_0282"
FT                   /id="PRO_0000106454"
FT   TRANSMEM        21..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          112..145
FT                   /note="TPR 1"
FT   REPEAT          149..182
FT                   /note="TPR 2"
SQ   SEQUENCE   239 AA;  26435 MW;  6483B788934BFE73 CRC64;
     MHEQRRGIVR VDRFLELHRR LLVGVLVAIL GGLGLSAGCL LVMTRLRARA SAEVTRIARE
     WDVLRKPDNT VSASGHEVEG RGGSSIRAKE DALLARLESC ASSPWRDGFA YAYAQACVAD
     IFFARKEWEK AQQAYVRAAY GARRSYVAGV YYFNAASCAD ERGRFEEARE LYQRSARVQD
     FPLVPRALFN VGRMEEALGR AAAATAAYMQ LYERFPLNGW AALGKSRAIA ISVGGGRAQ