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Y2839_DICDI
ID   Y2839_DICDI             Reviewed;         390 AA.
AC   Q558W0; Q6XUX4;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=HIT domain-containing protein DDB_G0272839;
GN   ORFNames=DDB_G0272839;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Chen Y., Huang C.-H.;
RT   "Identification of a putative gene in slime mold with homology to the human
RT   FHA-HIT gene.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- CAUTION: In contrast to other HIT domain proteins, lacks the conserved
CC       histidine triad motif (HXHXH), suggesting it has no hydrolase activity.
CC       {ECO:0000305}.
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DR   EMBL; AY208849; AAP86339.1; -; mRNA.
DR   EMBL; AAFI02000008; EAL71057.1; -; Genomic_DNA.
DR   RefSeq; XP_644956.1; XM_639864.1.
DR   AlphaFoldDB; Q558W0; -.
DR   SMR; Q558W0; -.
DR   STRING; 44689.DDB0201560; -.
DR   PaxDb; Q558W0; -.
DR   PRIDE; Q558W0; -.
DR   EnsemblProtists; EAL71057; EAL71057; DDB_G0272839.
DR   GeneID; 8618634; -.
DR   KEGG; ddi:DDB_G0272839; -.
DR   dictyBase; DDB_G0272839; -.
DR   eggNOG; KOG0562; Eukaryota.
DR   HOGENOM; CLU_708682_0_0_1; -.
DR   InParanoid; Q558W0; -.
DR   PRO; PR:Q558W0; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0033699; F:DNA 5'-adenosine monophosphate hydrolase activity; IBA:GO_Central.
DR   GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:1990165; F:single-strand break-containing DNA binding; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0006302; P:double-strand break repair; IBA:GO_Central.
DR   GO; GO:0000012; P:single strand break repair; IBA:GO_Central.
DR   Gene3D; 3.30.428.10; -; 1.
DR   InterPro; IPR026963; Aprataxin-like.
DR   InterPro; IPR011146; HIT-like.
DR   InterPro; IPR036265; HIT-like_sf.
DR   PANTHER; PTHR12486:SF4; PTHR12486:SF4; 1.
DR   SUPFAM; SSF54197; SSF54197; 1.
DR   PROSITE; PS51084; HIT_2; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..390
FT                   /note="HIT domain-containing protein DDB_G0272839"
FT                   /id="PRO_0000393722"
FT   DOMAIN          232..343
FT                   /note="HIT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00464"
FT   REGION          168..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..184
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        185..201
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        348
FT                   /note="H -> P (in Ref. 1; AAP86339)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   390 AA;  45107 MW;  2DBCEC98740FE139 CRC64;
     MNFKRLITTS FTNQIKNMKF KKTISFKPFD INNRIIYDKE PTIVFKDQKS CLLKDTISTT
     LEDGSKELKI KIGRFTPGLD SNNNYISSDI FEININNYSN KIDLCLNGKN PTFLRRKGKI
     PTKVKNWEQL LGEQLEIRKS VTLEDGDIIS FLGLNGTTSS IQFTIEEDNE NEKEKEKEME
     LDNDNTNTES IPPITSKSTS TSTSLIDTNK IQLKKHFEDP NSKNVGLSAL VYFCNKPESF
     LDVVLYYDDK TVAVLDKYPK AKHHYLVIPR VEINTLDELT PSFIPMLEHM YNVADAIINE
     IISKDNDDDN LKKSDFKLGF HAIPSMKRLH LHIISNDYNT KYLKNNKHWN SFTTEFYIPF
     DKILNELKSN GKVKVSIKKK IKKNKKKLIH
 
 
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