ID   Y2850_MYCTU             Reviewed;         629 AA.
AC   P9WPR3; L0TB22; O05809;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Uncharacterized protein Rv2850c;
GN   OrderedLocusNames=Rv2850c; ORFNames=MTCY24A1.07;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the Mg-chelatase subunits D/I family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP45651.1; -; Genomic_DNA.
DR   PIR; E70589; E70589.
DR   RefSeq; NP_217366.1; NC_000962.3.
DR   RefSeq; WP_003901481.1; NZ_NVQJ01000006.1.
DR   AlphaFoldDB; P9WPR3; -.
DR   SMR; P9WPR3; -.
DR   STRING; 83332.Rv2850c; -.
DR   iPTMnet; P9WPR3; -.
DR   PaxDb; P9WPR3; -.
DR   DNASU; 887364; -.
DR   GeneID; 45426837; -.
DR   GeneID; 887364; -.
DR   KEGG; mtu:Rv2850c; -.
DR   TubercuList; Rv2850c; -.
DR   eggNOG; COG1239; Bacteria.
DR   eggNOG; COG1240; Bacteria.
DR   OMA; YYHLPKA; -.
DR   PhylomeDB; P9WPR3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd01451; vWA_Magnesium_chelatase; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR   InterPro; IPR041702; BchD/ChlD_VWA.
DR   InterPro; IPR041628; ChlI/MoxR_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF07728; AAA_5; 1.
DR   Pfam; PF17863; AAA_lid_2; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Reference proteome.
FT   CHAIN           1..629
FT                   /note="Uncharacterized protein Rv2850c"
FT                   /id="PRO_0000206874"
FT   DOMAIN          451..587
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   REGION          308..395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        322..341
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        345..362
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0007744|PubMed:21969609"
SQ   SEQUENCE   629 AA;  66987 MW;  F4ACB04E3E5B526F CRC64;
     MKPYPFSAIV GHDRLRLALL LCAVRPEIGG ALIRGEKGTA KSTAVRGLAA LLSVATGSTE
     TGLVELPLGA TEDRVVGSLD LQRVMRDGEH AFSPGLLARA HGGVLYVDEV NLLHDHLVDI
     LLDAAAMGRV HVERDGISHS HEARFVLIGT MNPEEGELRP QLLDRFGLTV DVQASRDIDV
     RVQVIRRRMA YEADPDAFVA RYADADAELA HRIAAARATV DDVVLGDNEL RRIAALCAAF
     DVDGMRADLV VARTAAAHAA WRGVRTVEEQ DIRAAAELAL PHRRRRDPFD DHGIDRDQLD
     EALALASVDP EPEPDPPGGG QSANEPASQP NSRSKSTEPG APSSMGDDPP RPASPRLRSS
     PRPSAPPSKI FRTRALRVPG VGTGAPGRRS RARNASGSVV AAAEVSDPDA HGLHLFATLL
     AAGERAFGAG PLRPWPDDVR RAIREGREGN LVIFVVDASG SMAARDRMAA VSGATLSLLR
     DAYQRRDKVA VITFRQHEAT LLLSPTSSAH IAGRRLARFS TGGKTPLAEG LLAARALIIR
     EKVRDRARRP LVVVLTDGRA TAGPDPLGRS RTAAAGLVAE GAAAVVVDCE TSYVRLGLAA
     QLARQLGAPV VRLEQLHADY LVHAVRGVA