ID   Y2873_GEOSL             Reviewed;         605 AA.
AC   P61404;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=UPF0313 protein GSU2873 {ECO:0000255|HAMAP-Rule:MF_01251};
GN   OrderedLocusNames=GSU2873;
OS   Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Geobacteraceae; Geobacter.
OX   NCBI_TaxID=243231;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51573 / DSM 12127 / PCA;
RX   PubMed=14671304; DOI=10.1126/science.1088727;
RA   Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.C.,
RA   Heidelberg J.F., Wu D., Wu M., Ward N.L., Beanan M.J., Dodson R.J.,
RA   Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S.,
RA   Gwinn M.L., Kolonay J.F., Sullivan S.A., Haft D.H., Selengut J.,
RA   Davidsen T.M., Zafar N., White O., Tran B., Romero C., Forberger H.A.,
RA   Weidman J.F., Khouri H.M., Feldblyum T.V., Utterback T.R., Van Aken S.E.,
RA   Lovley D.R., Fraser C.M.;
RT   "Genome of Geobacter sulfurreducens: metal reduction in subsurface
RT   environments.";
RL   Science 302:1967-1969(2003).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01251};
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine.
CC       {ECO:0000255|HAMAP-Rule:MF_01251};
CC   -!- SIMILARITY: Belongs to the UPF0313 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01251}.
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DR   EMBL; AE017180; AAR36265.1; -; Genomic_DNA.
DR   RefSeq; NP_953915.1; NC_002939.5.
DR   RefSeq; WP_010943502.1; NC_002939.5.
DR   AlphaFoldDB; P61404; -.
DR   STRING; 243231.GSU2873; -.
DR   EnsemblBacteria; AAR36265; AAR36265; GSU2873.
DR   KEGG; gsu:GSU2873; -.
DR   PATRIC; fig|243231.5.peg.2901; -.
DR   eggNOG; COG1032; Bacteria.
DR   HOGENOM; CLU_018288_2_0_7; -.
DR   InParanoid; P61404; -.
DR   OMA; TCMYYTG; -.
DR   Proteomes; UP000000577; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.80.30.20; -; 1.
DR   HAMAP; MF_01251; UPF0313; 1.
DR   InterPro; IPR006638; Elp3/MiaB/NifB.
DR   InterPro; IPR020612; Methylthiotransferase_CS.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR023404; rSAM_horseshoe.
DR   InterPro; IPR022946; UPF0313.
DR   InterPro; IPR024560; UPF0313_C.
DR   InterPro; IPR013704; UPF0313_N.
DR   PANTHER; PTHR32331; PTHR32331; 1.
DR   Pfam; PF11842; DUF3362; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   Pfam; PF08497; Radical_SAM_N; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SFLD; SFLDG01069; UPF0313; 1.
DR   SMART; SM00729; Elp3; 1.
DR   TIGRFAMs; TIGR03904; SAM_YgiQ; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW   S-adenosyl-L-methionine.
FT   CHAIN           1..605
FT                   /note="UPF0313 protein GSU2873"
FT                   /id="PRO_0000076387"
FT   DOMAIN          291..561
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01266"
FT   REGION          586..605
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         305
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
FT   BINDING         309
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
FT   BINDING         312
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
SQ   SEQUENCE   605 AA;  67088 MW;  39BA12E2AC0DF63C CRC64;
     MSFLPVTRGE ALKRGWDELD IVFVTGDAYV DHPAFGVPLL ARWLEFHGFR VGIIPQPDWR
     SCEPFMALGR PRLFFAVSSG AMDSMVAHYT PARKLRHDDA YTPGNRHGAR PNRATIVYTS
     RLKEAYRDVP VVIGGIEASL RRFAHYDYWE DKVRRSLLLD AKADLLVHGM GERPILELAR
     RVRTGEPFQA IADIRGTAVV LGRGAAPPAG VVELPPFEEV AADRHRYAEA FRLLSREQNP
     HCAHPLVQRH GDRTLLCNPP AYPLEEAELD SVYALPFQRA PHPSHGEPIP AYEQIRASVT
     THRGCFGGCS FCAITHHQGK VIQSRSERSV LAEVERMAAM AWFRGSVSDV GGPTANMYGV
     HCGNTRGGHA CRRESCLYPS PCRYLAVGGE RGAALLRAVR GVRGVRNVAV SSGIRYDLME
     RQPAYFRELV AHHVGGLLKV APEHMVARVT DLMRKPGKES FDRFLERFRR ESARLGKKQY
     IIPYLMSGHP GCTLDDMVEL ALFLKRAGLR VEQVQDFTPT PGTLSTCMYH TGLDPFAGAP
     VHVPRGDREK RLQKALLLWH LPTERRNVLD ALRACGRESV ARELLGGAAG GGGGRSGSGF
     RPGRT