ID   Y2874_CLOAB             Reviewed;         385 AA.
AC   P45360; Q9R8D0;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   29-AUG-2001, sequence version 2.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Putative UDP-N-acetylglucosamine 2-epimerase;
DE            EC=5.1.3.14;
DE   AltName: Full=UDP-GlcNAc-2-epimerase;
GN   OrderedLocusNames=CA_C2874;
OS   Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS   / VKM B-1787).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=272562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX   PubMed=11466286; DOI=10.1128/jb.183.16.4823-4838.2001;
RA   Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA   Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA   Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA   Smith D.R.;
RT   "Genome sequence and comparative analysis of the solvent-producing
RT   bacterium Clostridium acetobutylicum.";
RL   J. Bacteriol. 183:4823-4838(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 144-385.
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RA   Winzer K., Lorenz K., Duerre P.;
RT   "Cloning, sequencing, and molecular analysis of two thiolase genes from
RT   Clostridium acetobutylicum DSM 792.";
RL   Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 332-385.
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX   PubMed=7867955; DOI=10.1016/0378-1119(94)00838-j;
RA   Stim-Herndon K.P., Petersen D.J., Bennett G.N.;
RT   "Characterization of an acetyl-CoA C-acetyltransferase (thiolase) gene from
RT   Clostridium acetobutylicum ATCC 824.";
RL   Gene 154:81-85(1995).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-
CC         mannosamine; Xref=Rhea:RHEA:17213, ChEBI:CHEBI:57705,
CC         ChEBI:CHEBI:68623; EC=5.1.3.14;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
CC       {ECO:0000305}.
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DR   EMBL; AE001437; AAK80817.1; -; Genomic_DNA.
DR   EMBL; AF072734; AAC26022.1; -; Genomic_DNA.
DR   EMBL; U08465; AAA82723.1; -; Genomic_DNA.
DR   PIR; F97253; F97253.
DR   PIR; PC4016; PC4016.
DR   RefSeq; NP_349477.1; NC_003030.1.
DR   RefSeq; WP_010966158.1; NC_003030.1.
DR   AlphaFoldDB; P45360; -.
DR   SMR; P45360; -.
DR   STRING; 272562.CA_C2874; -.
DR   EnsemblBacteria; AAK80817; AAK80817; CA_C2874.
DR   GeneID; 44999362; -.
DR   KEGG; cac:CA_C2874; -.
DR   PATRIC; fig|272562.8.peg.3058; -.
DR   eggNOG; COG0381; Bacteria.
DR   HOGENOM; CLU_041674_1_0_9; -.
DR   OMA; WFPYPEE; -.
DR   OrthoDB; 1117971at2; -.
DR   Proteomes; UP000000814; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR   InterPro; IPR029767; WecB-like.
DR   PANTHER; PTHR43174; PTHR43174; 1.
DR   Pfam; PF02350; Epimerase_2; 1.
DR   TIGRFAMs; TIGR00236; wecB; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Isomerase; Lipopolysaccharide biosynthesis; Reference proteome.
FT   CHAIN           1..385
FT                   /note="Putative UDP-N-acetylglucosamine 2-epimerase"
FT                   /id="PRO_0000208533"
FT   CONFLICT        286
FT                   /note="T -> A (in Ref. 2; AAC26022)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   385 AA;  43494 MW;  E5A300378D6C158B CRC64;
     MKQIKVISIF GTRPEAIKMA PLVRRLNENK NVESKVCVTA QHRQMLDQVL NLFDINPDFD
     LNIMKTKQTL TGITARVLEG LDKIFADENP DIVLVHGDTT TTFAAALAAF YKKIAVGHVE
     AGLRTYNKYF PFPEEMNRKL TGAVADLHFA PTLGSKKNLL REAVNEKNIF ITGNTVVDAM
     NHTVEKDYVF ENDELNKLDY KNKKVIMVTA HRRENWGKGI ENICTALRRI AEENEDVEIV
     YLVHLNPVVK DVVYNNLNGM KGVHLLPPLD TKETHNLMNK CFMVMTDSGG LQEEAPHLGK
     PVLVLRDVTE RPEAVEAGTV KLVGTDIKKI VDEAYKIMKD EEEYEKMSKA INPYGDGKAS
     DRIVDAILYH FGVLKDRPDE FSPKK