ID   Y287_MYCLE              Reviewed;         222 AA.
AC   O69601;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Uncharacterized membrane protein ML0287;
GN   OrderedLocusNames=ML0287; ORFNames=MLCB4.30;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DedA family. {ECO:0000305}.
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DR   EMBL; AL023514; CAA18951.1; -; Genomic_DNA.
DR   EMBL; AL583918; CAC29795.1; -; Genomic_DNA.
DR   PIR; G86944; G86944.
DR   RefSeq; NP_301327.1; NC_002677.1.
DR   RefSeq; WP_010907651.1; NC_002677.1.
DR   AlphaFoldDB; O69601; -.
DR   STRING; 272631.ML0287; -.
DR   EnsemblBacteria; CAC29795; CAC29795; CAC29795.
DR   KEGG; mle:ML0287; -.
DR   PATRIC; fig|272631.5.peg.451; -.
DR   Leproma; ML0287; -.
DR   eggNOG; COG0586; Bacteria.
DR   HOGENOM; CLU_044208_6_0_11; -.
DR   OMA; PWYGIGR; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR032818; DedA.
DR   InterPro; IPR032816; SNARE_assoc.
DR   PANTHER; PTHR30353; PTHR30353; 1.
DR   Pfam; PF09335; SNARE_assoc; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..222
FT                   /note="Uncharacterized membrane protein ML0287"
FT                   /id="PRO_0000161427"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   222 AA;  24348 MW;  F632290E3226FBCC CRC64;
     MNTAIVALPP TLDPMFWIGP EGFFAAAMLP ATLVIIFVET GLLFPLLPGE SLLFTGGLLA
     TKGTIDIWVL SPSVAVVAVL GDQIGYLIGR RIGPALFKKE NSRFFKQHYV TESHAFFEKH
     GRWTIILARF LPFMRTFTPV IAGLSYMSYP LYLGFDIVGG ILWGGGVTVA GYFLGNVPFV
     RQNLEKIILG ILFVSLLPAL IAAWHGYRSQ SRTAKSELAL PD