Y288_THEMA
ID Y288_THEMA Reviewed; 598 AA.
AC Q9WYC4;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Uncharacterized ABC transporter ATP-binding protein TM_0288;
GN OrderedLocusNames=TM_0288;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
CC -!- INTERACTION:
CC Q9WYC4; Q9WYC3: TM_0287; NbExp=4; IntAct=EBI-15975794, EBI-15975772;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; AE000512; AAD35376.1; -; Genomic_DNA.
DR PIR; F72396; F72396.
DR RefSeq; NP_228100.1; NC_000853.1.
DR RefSeq; WP_004083002.1; NZ_CP011107.1.
DR PDB; 3QF4; X-ray; 2.90 A; B=1-598.
DR PDB; 4Q4A; X-ray; 2.60 A; B=1-598.
DR PDB; 4Q4H; X-ray; 2.53 A; B=1-598.
DR PDB; 4Q4J; X-ray; 3.20 A; B=1-598.
DR PDB; 4Q7L; X-ray; 2.35 A; A/B/C=353-598.
DR PDB; 4Q7M; X-ray; 2.30 A; B=353-598.
DR PDB; 6QUZ; X-ray; 3.21 A; B/D=1-598.
DR PDB; 6QV0; X-ray; 3.12 A; B/D=1-598.
DR PDB; 6QV1; X-ray; 3.48 A; B/D=1-598.
DR PDB; 6QV2; X-ray; 4.23 A; B/D=1-598.
DR PDBsum; 3QF4; -.
DR PDBsum; 4Q4A; -.
DR PDBsum; 4Q4H; -.
DR PDBsum; 4Q4J; -.
DR PDBsum; 4Q7L; -.
DR PDBsum; 4Q7M; -.
DR PDBsum; 6QUZ; -.
DR PDBsum; 6QV0; -.
DR PDBsum; 6QV1; -.
DR PDBsum; 6QV2; -.
DR AlphaFoldDB; Q9WYC4; -.
DR SMR; Q9WYC4; -.
DR IntAct; Q9WYC4; 1.
DR STRING; 243274.THEMA_03285; -.
DR TCDB; 3.A.1.135.5; the atp-binding cassette (abc) superfamily.
DR ABCD; Q9WYC4; 12 sequenced antibodies.
DR DNASU; 897208; -.
DR EnsemblBacteria; AAD35376; AAD35376; TM_0288.
DR KEGG; tma:TM0288; -.
DR eggNOG; COG1132; Bacteria.
DR InParanoid; Q9WYC4; -.
DR OMA; LGIMLWG; -.
DR OrthoDB; 643917at2; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; PTHR24221; 1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF90123; SSF90123; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; Cell membrane; Membrane; Nucleotide-binding;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..598
FT /note="Uncharacterized ABC transporter ATP-binding protein
FT TM_0288"
FT /id="PRO_0000093279"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 39..322
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 355..589
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 388..395
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT HELIX 21..28
FT /evidence="ECO:0007829|PDB:4Q4H"
FT TURN 29..31
FT /evidence="ECO:0007829|PDB:4Q4H"
FT HELIX 33..35
FT /evidence="ECO:0007829|PDB:4Q4H"
FT HELIX 36..66
FT /evidence="ECO:0007829|PDB:4Q4H"
FT TURN 67..71
FT /evidence="ECO:0007829|PDB:4Q4H"
FT HELIX 73..75
FT /evidence="ECO:0007829|PDB:4Q4A"
FT HELIX 76..122
FT /evidence="ECO:0007829|PDB:4Q4H"
FT HELIX 125..130
FT /evidence="ECO:0007829|PDB:4Q4H"
FT HELIX 133..152
FT /evidence="ECO:0007829|PDB:4Q4H"
FT HELIX 154..175
FT /evidence="ECO:0007829|PDB:4Q4H"
FT HELIX 177..183
FT /evidence="ECO:0007829|PDB:4Q4H"
FT HELIX 186..224
FT /evidence="ECO:0007829|PDB:4Q4H"
FT HELIX 226..231
FT /evidence="ECO:0007829|PDB:4Q4H"
FT TURN 232..234
FT /evidence="ECO:0007829|PDB:6QV0"
FT HELIX 235..259
FT /evidence="ECO:0007829|PDB:4Q4H"
FT TURN 260..262
FT /evidence="ECO:0007829|PDB:3QF4"
FT HELIX 263..287
FT /evidence="ECO:0007829|PDB:4Q4H"
FT STRAND 288..290
FT /evidence="ECO:0007829|PDB:6QV1"
FT HELIX 293..301
FT /evidence="ECO:0007829|PDB:4Q4H"
FT TURN 302..306
FT /evidence="ECO:0007829|PDB:4Q4H"
FT HELIX 308..333
FT /evidence="ECO:0007829|PDB:4Q4H"
FT STRAND 355..362
FT /evidence="ECO:0007829|PDB:4Q7M"
FT STRAND 364..368
FT /evidence="ECO:0007829|PDB:4Q7M"
FT STRAND 370..378
FT /evidence="ECO:0007829|PDB:4Q7M"
FT STRAND 383..387
FT /evidence="ECO:0007829|PDB:4Q7M"
FT HELIX 394..401
FT /evidence="ECO:0007829|PDB:4Q7M"
FT STRAND 408..414
FT /evidence="ECO:0007829|PDB:4Q7M"
FT HELIX 419..421
FT /evidence="ECO:0007829|PDB:4Q7M"
FT HELIX 424..429
FT /evidence="ECO:0007829|PDB:4Q7M"
FT STRAND 431..434
FT /evidence="ECO:0007829|PDB:4Q7M"
FT STRAND 442..444
FT /evidence="ECO:0007829|PDB:4Q7M"
FT HELIX 445..449
FT /evidence="ECO:0007829|PDB:4Q7M"
FT TURN 450..452
FT /evidence="ECO:0007829|PDB:4Q7M"
FT HELIX 458..467
FT /evidence="ECO:0007829|PDB:4Q7M"
FT HELIX 471..475
FT /evidence="ECO:0007829|PDB:4Q7M"
FT STRAND 477..479
FT /evidence="ECO:0007829|PDB:6QV0"
FT HELIX 480..482
FT /evidence="ECO:0007829|PDB:4Q7M"
FT HELIX 486..489
FT /evidence="ECO:0007829|PDB:4Q7M"
FT HELIX 494..507
FT /evidence="ECO:0007829|PDB:4Q7M"
FT STRAND 511..516
FT /evidence="ECO:0007829|PDB:4Q7M"
FT TURN 517..519
FT /evidence="ECO:0007829|PDB:6QV1"
FT STRAND 520..522
FT /evidence="ECO:0007829|PDB:4Q7L"
FT HELIX 524..538
FT /evidence="ECO:0007829|PDB:4Q7M"
FT STRAND 541..546
FT /evidence="ECO:0007829|PDB:4Q7M"
FT HELIX 552..555
FT /evidence="ECO:0007829|PDB:4Q7M"
FT STRAND 557..563
FT /evidence="ECO:0007829|PDB:4Q7M"
FT STRAND 566..571
FT /evidence="ECO:0007829|PDB:4Q7M"
FT HELIX 573..579
FT /evidence="ECO:0007829|PDB:4Q7M"
FT HELIX 582..591
FT /evidence="ECO:0007829|PDB:4Q7M"
FT HELIX 592..596
FT /evidence="ECO:0007829|PDB:3QF4"
SQ SEQUENCE 598 AA; 67708 MW; BDFA5A242F18393E CRC64;
MPEIRRRPHG PILEKPALKN PTATLRRLLG YLRPHTFTLI MVFVFVTVSS ILGVLSPYLI
GKTIDVVFVP RRFDLLPRYM LILGTIYALT SLLFWLQGKI MLTLSQDVVF RLRKELFEKL
QRVPVGFFDR TPHGDIISRV INDVDNINNV LGNSIIQFFS GIVTLAGAVI MMFRVNVILS
LVTLSIVPLT VLITQIVSSQ TRKYFYENQR VLGQLNGIIE EDISGLTVIK LFTREEKEME
KFDRVNESLR KVGTKAQIFS GVLPPLMNMV NNLGFALISG FGGWLALKDI ITVGTIATFI
GYSRQFTRPL NELSNQFNMI QMALASAERI FEILDLEEEK DDPDAVELRE VRGEIEFKNV
WFSYDKKKPV LKDITFHIKP GQKVALVGPT GSGKTTIVNL LMRFYDVDRG QILVDGIDIR
KIKRSSLRSS IGIVLQDTIL FSTTVKENLK YGNPGATDEE IKEAAKLTHS DHFIKHLPEG
YETVLTDNGE DLSQGQRQLL AITRAFLANP KILILDEATS NVDTKTEKSI QAAMWKLMEG
KTSIIIAHRL NTIKNADLII VLRDGEIVEM GKHDELIQKR GFYYELFTSQ YGLVVEKE
