ID   Y2897_MYCTU             Reviewed;         503 AA.
AC   P9WPR1; L0TCK1; P68909; Q10818;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Uncharacterized protein Rv2897c;
GN   OrderedLocusNames=Rv2897c; ORFNames=MTCY274.28c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the Mg-chelatase subunits D/I family. ComM
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45699.1; -; Genomic_DNA.
DR   PIR; D70926; D70926.
DR   RefSeq; NP_217413.1; NC_000962.3.
DR   RefSeq; WP_003414700.1; NZ_NVQJ01000006.1.
DR   AlphaFoldDB; P9WPR1; -.
DR   STRING; 83332.Rv2897c; -.
DR   PaxDb; P9WPR1; -.
DR   DNASU; 888212; -.
DR   GeneID; 45426884; -.
DR   GeneID; 888212; -.
DR   KEGG; mtu:Rv2897c; -.
DR   TubercuList; Rv2897c; -.
DR   eggNOG; COG0606; Bacteria.
DR   OMA; STNPCPC; -.
DR   PhylomeDB; P9WPR1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR045006; CHLI-like.
DR   InterPro; IPR004482; Mg_chelat-rel.
DR   InterPro; IPR025158; Mg_chelat-rel_C.
DR   InterPro; IPR000523; Mg_chelatse_chII-like_cat_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR32039; PTHR32039; 1.
DR   PANTHER; PTHR32039:SF7; PTHR32039:SF7; 1.
DR   Pfam; PF01078; Mg_chelatase; 1.
DR   Pfam; PF13335; Mg_chelatase_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   TIGRFAMs; TIGR00368; TIGR00368; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..503
FT                   /note="Uncharacterized protein Rv2897c"
FT                   /id="PRO_0000206880"
SQ   SEQUENCE   503 AA;  52913 MW;  C20972DFCB9071CC CRC64;
     MALGRAFSVA VRGLDGEIVE IEADITSGLP GVHLVGLPDA ALQESRDRVR AAVTNCGNSW
     PMARLTLALS PATLPKMGSV YDIALAAAVL SAQQKKPWER LENTLLLGEL SLDGRVRPVR
     GVLPAVLAAK RDGWPAVVVP ADNLPEASLV DGIDVRGVRT LGQLQSWLRG STGLAGRITT
     ADTTPESAAD LADVVGQSQA RFAVEVAAAG AHHLMLTGPP GVGKTMLAQR LPGLLPSLSG
     SESLEVTAIH SVAGLLSGDT PLITRPPFVA PHHSSSVAAL VGGGSGMARP GAVSRAHRGV
     LFLDECAEIS LSALEALRTP LEDGEIRLAR RDGVACYPAR FQLVLAANPC PCAPADPQDC
     ICAAATKRRY LGKLSGPLLD RVDLRVQMHR LRAGAFSAAD GESTSQVRQR VALAREAAAQ
     RWRPHGFRTN AEVSGPLLRR KFRPSSAAML PLRTALDRGL LSIRGVDRTL RVAWSLADLA
     GRTSPGIDEV AAALSFRQTG ARR