ID   Y2900_MYCTO             Reviewed;         779 AA.
AC   P9WJP8; L0TDW4; P65408; Q10821;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Uncharacterized oxidoreductase MT2968;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=MT2968;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000305};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000305};
CC   -!- COFACTOR:
CC       Name=Mo-bis(molybdopterin guanine dinucleotide);
CC         Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000250};
CC       Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-
CC       bis-MGD) cofactor per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC       oxidoreductase family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK47294.1; -; Genomic_DNA.
DR   PIR; G70926; G70926.
DR   RefSeq; WP_003899532.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJP8; -.
DR   SMR; P9WJP8; -.
DR   EnsemblBacteria; AAK47294; AAK47294; MT2968.
DR   KEGG; mtc:MT2968; -.
DR   PATRIC; fig|83331.31.peg.3208; -.
DR   HOGENOM; CLU_000422_16_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:InterPro.
DR   GO; GO:0030151; F:molybdenum ion binding; IEA:InterPro.
DR   GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR   CDD; cd02787; MopB_CT_ydeP; 1.
DR   CDD; cd02767; MopB_ydeP; 1.
DR   InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR   InterPro; IPR037951; MopB_CT_YdeP.
DR   InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR   InterPro; IPR006656; Mopterin_OxRdtase.
DR   InterPro; IPR010046; Mopterin_OxRdtse_a_bac.
DR   InterPro; IPR041953; YdeP_MopB.
DR   PANTHER; PTHR43105:SF4; PTHR43105:SF4; 1.
DR   Pfam; PF00384; Molybdopterin; 1.
DR   Pfam; PF01568; Molydop_binding; 1.
DR   SUPFAM; SSF50692; SSF50692; 1.
DR   TIGRFAMs; TIGR01701; Fdhalpha-like; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Molybdenum; Oxidoreductase.
FT   CHAIN           1..779
FT                   /note="Uncharacterized oxidoreductase MT2968"
FT                   /id="PRO_0000427792"
FT   BINDING         72
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000250"
FT   BINDING         75
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   779 AA;  84566 MW;  382FB089071E8E54 CRC64;
     MYVEAVRWQR SAASRDVLAD YDEQAVTVAP RKREAAGVRA VMVSLQRGMQ QMGALRTAAA
     LARLNQRNGF DCPGCAWPEE PGGRKLAEFC ENGAKAVAEE ATKRTVTAEF FARHSVAELS
     AKPEYWLSQQ GRLAHPMVLR PGDDHYRPIS WDAAYQLIAE QLNGLDSPDR AVFYTSGRTS
     NEAAFCYQLL VRSFGTNNLP DCSNMCHESS GAALTDSIGI GKGSVTIGDV EHADLIVIAG
     QNPGTNHPRM LSVLGKAKAN GAKIIAVNPL PEAGLIRFKD PQKVNGVVGH GIPIADEFVQ
     IRLGGDMALF AGLGRLLLEA EERVPGSVVD RSFVDNHCAG FDGYRRRTLQ VGLDTVMDAT
     GIELAQLQRV AAMLMASQRT VICWAMGLTQ HAHAVATIGE VTNVLLLRGM IGKPGAGVCP
     VRGHSNVQGD RTMGIWEKMP EQFLAALDRE FGITSPRAHG FDTVAAIRAM RDGRVSVFMG
     MGGNFASATP DTAVTEAALR RCALTVQVST KLNRSHLVHG ATALILPTLG RTDRDTRNGR
     KQLVSVEDSM SMVHLSRGSL HPPSDQVRSE VQIICQLARA LFGPGHPVPW ERFADDYDTI
     RDAIAAVVPG CDDYNHKVRV PDGFQLPHPP RDAREFRTST GKANFAVNPL QWVPVPPGRL
     VLQTLRSHDQ YNTTIYGLDD RYRGVKGGRR VVFINPADIE TFGLTAGDRV DLVSEWTDGQ
     GGLQERRAKD FLVVAYSTPV GNAAAYYPET NPLVPLDHTA AQSNTPVSKA IIVRLEPTA