Y2900_MYCTU
ID Y2900_MYCTU Reviewed; 779 AA.
AC P9WJP9; L0TDW4; P65408; Q10821;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 40.
DE RecName: Full=Uncharacterized oxidoreductase Rv2900c;
DE EC=1.-.-.-;
GN OrderedLocusNames=Rv2900c; ORFNames=MTCY274.31c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA Raman K., Yeturu K., Chandra N.;
RT "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT through an interactome, reactome and genome-scale structural analysis.";
RL BMC Syst. Biol. 2:109-109(2008).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000305};
CC Note=Binds 1 [4Fe-4S] cluster. {ECO:0000305};
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000250};
CC Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-
CC bis-MGD) cofactor per subunit. {ECO:0000250};
CC -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC oxidoreductase family. {ECO:0000305}.
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DR EMBL; AL123456; CCP45702.1; -; Genomic_DNA.
DR PIR; G70926; G70926.
DR RefSeq; NP_217416.1; NC_000962.3.
DR RefSeq; WP_003899532.1; NZ_NVQJ01000006.1.
DR AlphaFoldDB; P9WJP9; -.
DR SMR; P9WJP9; -.
DR STRING; 83332.Rv2900c; -.
DR PaxDb; P9WJP9; -.
DR PRIDE; P9WJP9; -.
DR DNASU; 887987; -.
DR GeneID; 887987; -.
DR KEGG; mtu:Rv2900c; -.
DR TubercuList; Rv2900c; -.
DR eggNOG; COG0243; Bacteria.
DR OMA; DCSDLCH; -.
DR PhylomeDB; P9WJP9; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0030151; F:molybdenum ion binding; IEA:InterPro.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR CDD; cd02787; MopB_CT_ydeP; 1.
DR CDD; cd02767; MopB_ydeP; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR037951; MopB_CT_YdeP.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR010046; Mopterin_OxRdtse_a_bac.
DR InterPro; IPR041953; YdeP_MopB.
DR PANTHER; PTHR43105:SF4; PTHR43105:SF4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR SUPFAM; SSF50692; SSF50692; 1.
DR TIGRFAMs; TIGR01701; Fdhalpha-like; 1.
PE 1: Evidence at protein level;
KW 4Fe-4S; Iron; Iron-sulfur; Metal-binding; Molybdenum; Oxidoreductase;
KW Reference proteome.
FT CHAIN 1..779
FT /note="Uncharacterized oxidoreductase Rv2900c"
FT /id="PRO_0000063243"
FT BINDING 72
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000250"
FT BINDING 75
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000250"
SQ SEQUENCE 779 AA; 84566 MW; 382FB089071E8E54 CRC64;
MYVEAVRWQR SAASRDVLAD YDEQAVTVAP RKREAAGVRA VMVSLQRGMQ QMGALRTAAA
LARLNQRNGF DCPGCAWPEE PGGRKLAEFC ENGAKAVAEE ATKRTVTAEF FARHSVAELS
AKPEYWLSQQ GRLAHPMVLR PGDDHYRPIS WDAAYQLIAE QLNGLDSPDR AVFYTSGRTS
NEAAFCYQLL VRSFGTNNLP DCSNMCHESS GAALTDSIGI GKGSVTIGDV EHADLIVIAG
QNPGTNHPRM LSVLGKAKAN GAKIIAVNPL PEAGLIRFKD PQKVNGVVGH GIPIADEFVQ
IRLGGDMALF AGLGRLLLEA EERVPGSVVD RSFVDNHCAG FDGYRRRTLQ VGLDTVMDAT
GIELAQLQRV AAMLMASQRT VICWAMGLTQ HAHAVATIGE VTNVLLLRGM IGKPGAGVCP
VRGHSNVQGD RTMGIWEKMP EQFLAALDRE FGITSPRAHG FDTVAAIRAM RDGRVSVFMG
MGGNFASATP DTAVTEAALR RCALTVQVST KLNRSHLVHG ATALILPTLG RTDRDTRNGR
KQLVSVEDSM SMVHLSRGSL HPPSDQVRSE VQIICQLARA LFGPGHPVPW ERFADDYDTI
RDAIAAVVPG CDDYNHKVRV PDGFQLPHPP RDAREFRTST GKANFAVNPL QWVPVPPGRL
VLQTLRSHDQ YNTTIYGLDD RYRGVKGGRR VVFINPADIE TFGLTAGDRV DLVSEWTDGQ
GGLQERRAKD FLVVAYSTPV GNAAAYYPET NPLVPLDHTA AQSNTPVSKA IIVRLEPTA
