ID   Y292_MYCPN              Reviewed;         309 AA.
AC   P75485;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Uncharacterized RNA pseudouridine synthase MG209 homolog;
DE            EC=5.4.99.-;
DE   AltName: Full=RNA pseudouridylate synthase;
DE   AltName: Full=RNA-uridine isomerase;
GN   OrderedLocusNames=MPN_292; ORFNames=H10_orf309, MP543;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS   pneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in RNA = a pseudouridine in RNA;
CC         Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
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DR   EMBL; U00089; AAB96191.1; -; Genomic_DNA.
DR   PIR; S73869; S73869.
DR   RefSeq; NP_109980.1; NC_000912.1.
DR   RefSeq; WP_010874649.1; NC_000912.1.
DR   AlphaFoldDB; P75485; -.
DR   SMR; P75485; -.
DR   IntAct; P75485; 4.
DR   STRING; 272634.MPN_292; -.
DR   EnsemblBacteria; AAB96191; AAB96191; MPN_292.
DR   KEGG; mpn:MPN_292; -.
DR   PATRIC; fig|272634.6.peg.316; -.
DR   HOGENOM; CLU_016902_4_4_14; -.
DR   OMA; AHPSPGW; -.
DR   BioCyc; MPNE272634:G1GJ3-460-MON; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProt.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   Pfam; PF01479; S4; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00005; rluA_subfam; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome; RNA-binding.
FT   CHAIN           1..309
FT                   /note="Uncharacterized RNA pseudouridine synthase MG209
FT                   homolog"
FT                   /id="PRO_0000162740"
FT   DOMAIN          11..87
FT                   /note="S4 RNA-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT   ACT_SITE        131
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   309 AA;  35229 MW;  7F2D8135F9C75A40 CRC64;
     MEQTFSVTTA QRLDTFLATL LNLSRVKVAK LIVDGLVSVN GKKITKNGWL VQPEDRVHVN
     WSEELFEKVP VEVQPYDFPL DILYEDEQIM VVNKPNGLIS HPTSFNESES LLGAALFHCN
     HQPVFLVHRL DRDTSGVIML AKNQSSLLHL QKQLQQRVMK RYYLALVHFP LDSLSGTISA
     PLERVGNNKV MWKVGNSSNK AKNAFTKFTV LNQNEKAALI KCELLTGRTH QIRVHLQFIK
     HPVYNDPLYG LKSEQATEYG QYLHAQQISF IHPTLNKEMG FEAQLDKTFS DKLDNLNLKI
     ANSLYALFQ