Y293_HAEIN
ID Y293_HAEIN Reviewed; 128 AA.
AC P44617;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Probable heavy metal-dependent transcriptional regulator HI_0293;
GN OrderedLocusNames=HI_0293;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Could be a copper-dependent transcriptional activator of the
CC ATPase HI_0290.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- DOMAIN: It contains a N-terminal DNA binding region and a C-terminal
CC metal binding region. {ECO:0000250}.
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DR EMBL; L42023; AAC21957.1; -; Genomic_DNA.
DR PIR; I64059; I64059.
DR RefSeq; NP_438460.1; NC_000907.1.
DR RefSeq; WP_005654127.1; NC_000907.1.
DR AlphaFoldDB; P44617; -.
DR SMR; P44617; -.
DR STRING; 71421.HI_0293; -.
DR EnsemblBacteria; AAC21957; AAC21957; HI_0293.
DR KEGG; hin:HI_0293; -.
DR PATRIC; fig|71421.8.peg.309; -.
DR eggNOG; COG0789; Bacteria.
DR HOGENOM; CLU_060077_2_0_6; -.
DR OMA; HTLAFIK; -.
DR PhylomeDB; P44617; -.
DR BioCyc; HINF71421:G1GJ1-311-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd01108; HTH_CueR; 1.
DR InterPro; IPR011789; CueR.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR InterPro; IPR015358; Tscrpt_reg_MerR_DNA-bd.
DR Pfam; PF00376; MerR; 1.
DR Pfam; PF09278; MerR-DNA-bind; 1.
DR PRINTS; PR00040; HTHMERR.
DR SMART; SM00422; HTH_MERR; 1.
DR SUPFAM; SSF46955; SSF46955; 1.
DR TIGRFAMs; TIGR02044; CueR; 1.
DR PROSITE; PS00552; HTH_MERR_1; 1.
DR PROSITE; PS50937; HTH_MERR_2; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..128
FT /note="Probable heavy metal-dependent transcriptional
FT regulator HI_0293"
FT /id="PRO_0000098167"
FT DOMAIN 1..69
FT /note="HTH merR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT DNA_BIND 4..23
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
SQ SEQUENCE 128 AA; 14589 MW; 84D1381E09174CAE CRC64;
MNISEAAKLV GLSTKQIRDY EKMGLIKPAV RSLSGYRNYG ESDLERLHFI RHSRNVGFSL
HQIAQLLALQ DNPKRSCREV KVLTAQHIAT LNQQIEQLQK MVQKLQHWHD SCQGNDNPEC
LILNGLNG
