ID   Y2971_MYCTO             Reviewed;         282 AA.
AC   P9WQA4; L0TBF0; P95124; Q7D6C1;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Uncharacterized oxidoreductase MT3049;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=MT3049;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK47375.1; -; Genomic_DNA.
DR   PIR; H70671; H70671.
DR   RefSeq; WP_003899563.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WQA4; -.
DR   SMR; P9WQA4; -.
DR   EnsemblBacteria; AAK47375; AAK47375; MT3049.
DR   KEGG; mtc:MT3049; -.
DR   PATRIC; fig|83331.31.peg.3291; -.
DR   HOGENOM; CLU_023205_0_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; PTHR43827; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..282
FT                   /note="Uncharacterized oxidoreductase MT3049"
FT                   /id="PRO_0000426810"
FT   ACT_SITE        57
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         115
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         195..247
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   282 AA;  30364 MW;  DA316780633D7E60 CRC64;
     MTGESGAAAA PSITLNDEHT MPVLGLGVAE LSDDETERAV SAALEIGCRL IDTAYAYGNE
     AAVGRAIAAS GVAREELFVT TKLATPDQGF TRSQEACRAS LDRLGLDYVD LYLIHWPAPP
     VGKYVDAWGG MIQSRGEGHA RSIGVSNFTA ENIENLIDLT FVTPAVNQIE LHPLLNQDEL
     RKANAQHTVV TQSYCPLALG RLLDNPTVTS IASEYVKTPA QVLLRWNLQL GNAVVVRSAR
     PERIASNFDV FDFELAAEHM DALGGLNDGT RVREDPLTYA GT