ID   Y2993_MYCBP             Reviewed;         282 AA.
AC   A1KMW6;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Uncharacterized oxidoreductase BCG_2993;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=BCG_2993;
OS   Mycobacterium bovis (strain BCG / Pasteur 1173P2).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=410289;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCG / Pasteur 1173P2;
RX   PubMed=17372194; DOI=10.1073/pnas.0700869104;
RA   Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P.,
RA   Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K.,
RA   Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C.,
RA   Barrell B.G., Parkhill J., Cole S.T.;
RT   "Genome plasticity of BCG and impact on vaccine efficacy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007).
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
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DR   EMBL; AM408590; CAL72982.1; -; Genomic_DNA.
DR   RefSeq; WP_003415022.1; NC_008769.1.
DR   AlphaFoldDB; A1KMW6; -.
DR   SMR; A1KMW6; -.
DR   GeneID; 45426960; -.
DR   KEGG; mbb:BCG_2993; -.
DR   HOGENOM; CLU_023205_0_1_11; -.
DR   OMA; KLWPTDQ; -.
DR   Proteomes; UP000001472; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; PTHR43827; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..282
FT                   /note="Uncharacterized oxidoreductase BCG_2993"
FT                   /id="PRO_0000380733"
FT   ACT_SITE        57
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         115
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         195..247
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   282 AA;  30387 MW;  DDAF65BE669D7E60 CRC64;
     MTGESGAAAA PSITLNDEHT MPVLGLGVAE LSDDETERAV SAALEIGCRL IDTAYAYGNE
     AAVGRAIAAS GVAREELFVT TKLATPDQGF TRSQEACRAS LDRLGLDYVD LYLIHWPAPP
     VGKYVDAWGG MIQSRGEGHA RSIGVSNFTA EHIENLIDLT FVTPAVNQIE LHPLLNQDEL
     RKANAQHTVV TQSYCPLALG RLLDNPTVTS IASEYVKTPA QVLLRWNLQL GNAVVVRSAR
     PERIASNFDV FDFELAAEHM DALGGLNDGT RVREDPLTYA GT