ID   Y2993_MYCTU             Reviewed;         265 AA.
AC   I6Y276;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-AUG-2022, sequence version 3.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Protein Rv2993c;
GN   OrderedLocusNames=Rv2993c {ECO:0000312|EMBL:CCP45798.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1] {ECO:0000312|EMBL:CCP45798.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2] {ECO:0007744|PubMed:21969609}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [3]
RP   PROTEIN SEQUENCE OF 20-54 AND 83-98, AND SEQUENCE REVISION TO N-TERMINUS.
RC   STRAIN=H37Rv;
RX   PubMed=34915127; DOI=10.1016/j.ygeno.2021.12.001;
RA   Shi J., Meng S., Wan L., Zhang Z., Jiang S., Zhu H., Dai E., Chang L.,
RA   Gao H., Wan K., Zhang L., Zhao X., Liu H., Lyu Z., Zhang Y., Xu P.;
RT   "Deep N-terminomics of Mycobacterium tuberculosis H37Rv extensively correct
RT   annotated encoding genes.";
RL   Genomics 114:292-304(2022).
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000250|UniProtKB:P37352};
CC   -!- SIMILARITY: In the C-terminal section; belongs to the FAH family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CCP45798.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000269|PubMed:34915127};
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DR   EMBL; AL123456; CCP45798.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_217509.3; NC_000962.3.
DR   RefSeq; WP_003901510.1; NC_000962.3.
DR   SMR; I6Y276; -.
DR   STRING; 83332.Rv2993c; -.
DR   PaxDb; I6Y276; -.
DR   PRIDE; I6Y276; -.
DR   DNASU; 887867; -.
DR   GeneID; 887867; -.
DR   KEGG; mtu:Rv2993c; -.
DR   PATRIC; fig|83332.111.peg.3336; -.
DR   TubercuList; Rv2993c; -.
DR   eggNOG; COG0179; Bacteria.
DR   OMA; WGRKIIC; -.
DR   PhylomeDB; I6Y276; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0018773; F:acetylpyruvate hydrolase activity; IBA:GO_Central.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.850.10; -; 1.
DR   InterPro; IPR018833; DUF2437.
DR   InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR   InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR   Pfam; PF10370; DUF2437; 1.
DR   Pfam; PF01557; FAA_hydrolase; 1.
DR   SUPFAM; SSF56529; SSF56529; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Metal-binding; Reference proteome.
FT   CHAIN           1..265
FT                   /note="Protein Rv2993c"
FT                   /id="PRO_0000456000"
FT   BINDING         114
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250|UniProtKB:P37352"
FT   BINDING         116
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250|UniProtKB:P37352"
FT   BINDING         145
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250|UniProtKB:P37352"
SQ   SEQUENCE   265 AA;  27998 MW;  4F2A6C1E61F14C01 CRC64;
     MRIGRIASPD GVAFASIDGE LGEPSEMTAR EIAEHPFGTP TFTGRSWPLA DVRLLAPILA
     SKVVCVGKNY ADHIAEMGGR PPADPVIFLK PNTAIIGPNT PIRLPANASP VHFEGELAIV
     IGRACKDVPA AQAVDNILGY TIGNDVSARD QQQSDGQWTR AKGHDTFCPV GPWIVTDLAP
     FDPADLELRT VVNGDVKQHA RTSLMIHDIG AIVEWISAIM TLLPGDLILT GTPAGVGPIE
     DGDTVSITIE GIGTLTNPVV RKGKP