ID   Y2994_MYCTU             Reviewed;         445 AA.
AC   P9WJW7; L0TCU9; Q7ARU7; Q8VJ95;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Uncharacterized MFS-type transporter Rv2994;
GN   OrderedLocusNames=Rv2994;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP45799.1; -; Genomic_DNA.
DR   PIR; E70854; E70854.
DR   RefSeq; NP_217510.1; NC_000962.3.
DR   RefSeq; WP_003415142.1; NC_000962.3.
DR   AlphaFoldDB; P9WJW7; -.
DR   SMR; P9WJW7; -.
DR   STRING; 83332.Rv2994; -.
DR   PaxDb; P9WJW7; -.
DR   DNASU; 888200; -.
DR   GeneID; 888200; -.
DR   KEGG; mtu:Rv2994; -.
DR   PATRIC; fig|83332.12.peg.3341; -.
DR   TubercuList; Rv2994; -.
DR   eggNOG; COG2271; Bacteria.
DR   OMA; FGTVFLH; -.
DR   PhylomeDB; P9WJW7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..445
FT                   /note="Uncharacterized MFS-type transporter Rv2994"
FT                   /id="PRO_0000390686"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          417..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   445 AA;  47046 MW;  FE44EAE042E71784 CRC64;
     MSRDPTGVGA RWAIMIVSLG VTASSFLFIN GVAFLIPRLE NARGTPLSHA GLLASMPSWG
     LVVTMFAWGY LLDHVGERMV MAVGSALTAA AAYAAASVHS LLWIGVFLFL GGMAAGGCNS
     AGGRLVSGWF PPQQRGLAMG IRQTAQPLGI ASGALVIPEL AERGVHAGLM FPAVVCTLAA
     VASVLGIVDP PRKSRTKASE QELASPYRGS SILWRIHAAS ALLMMPQTVT VTFMLVWLIN
     HHGWSVAQAG VLVTISQLLG ALGRVAVGRW SDHVGSRMRP VRLIAAAAAA TLFLLAAVDN
     EGSRYDVLLM IAISVIAVLD NGLEATAITE YAGPYWSGRA LGIQNTTQRL MAAAGPPLFG
     SLITTAAYPT AWALCGVFPL AAVPLVPVRL LPPGLETRAR RQSVRRHRWW QAVRCHAWPN
     GPRRPGPPGQ PRRVRQGGTA ITPPT