ID   Y299_MYCTU              Reviewed;         100 AA.
AC   O07226; L0T4Y8;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Toxin Rv0299;
GN   OrderedLocusNames=Rv0299;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   EXPRESSION IN M.SMEGMATIS, AND FUNCTION AS A TOXIN.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA   Ramage H.R., Connolly L.E., Cox J.S.;
RT   "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT   antitoxin systems: implications for pathogenesis, stress responses, and
RT   evolution.";
RL   PLoS Genet. 5:E1000767-E1000767(2009).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system.
CC       Upon expression in M.smegmatis inhibits colony formation. Its toxic
CC       effect is neutralized by coexpression with cognate antitoxin
CC       Rv0298/MT0312. {ECO:0000269|PubMed:20011113}.
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DR   EMBL; AL123456; CCP43029.1; -; Genomic_DNA.
DR   PIR; D70523; D70523.
DR   RefSeq; NP_214813.1; NC_000962.3.
DR   RefSeq; WP_003401560.1; NZ_NVQJ01000026.1.
DR   AlphaFoldDB; O07226; -.
DR   STRING; 83332.Rv0299; -.
DR   PaxDb; O07226; -.
DR   DNASU; 886598; -.
DR   GeneID; 886598; -.
DR   KEGG; mtu:Rv0299; -.
DR   TubercuList; Rv0299; -.
DR   eggNOG; ENOG5032DWV; Bacteria.
DR   OMA; APRRDNE; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0045926; P:negative regulation of growth; IMP:MTBBASE.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..100
FT                   /note="Toxin Rv0299"
FT                   /id="PRO_0000406883"
SQ   SEQUENCE   100 AA;  10442 MW;  FB042DBFAD8F1076 CRC64;
     MIAPGDIAPR RDSEHELYVA VLSNALHRAA DTGRVITCPF IPGRVPEDLL AMVVAVEQPN
     GTLLPELVQW LHVAALGAPL GNAGVAALRE AASVVTALLC