ID   Y2R2_DROME              Reviewed;        1021 AA.
AC   P16425;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Putative 115 kDa protein in type-1 retrotransposable element R1DM;
DE   AltName: Full=ORF 2;
DE   AltName: Full=Putative 115 kDa protein in type I retrotransposable element R1DM;
GN   Name=R1A1-element\ORF2;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Oregon-R;
RX   PubMed=1690812; DOI=10.1016/0022-2836(90)90303-4;
RA   Jakubczak J.L., Xiong Y., Eickbush T.H.;
RT   "Type I (R1) and type II (R2) ribosomal DNA insertions of Drosophila
RT   melanogaster are retrotransposable elements closely related to those of
RT   Bombyx mori.";
RL   J. Mol. Biol. 212:37-52(1990).
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DR   EMBL; X51968; CAA36227.1; -; Genomic_DNA.
DR   PIR; S09111; S09111.
DR   AlphaFoldDB; P16425; -.
DR   SMR; P16425; -.
DR   PRIDE; P16425; -.
DR   FlyBase; FBgn0044824; R1A1-element\ORF2.
DR   PRO; PR:P16425; -.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.60.10.10; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56219; SSF56219; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Transposable element.
FT   CHAIN           1..1021
FT                   /note="Putative 115 kDa protein in type-1 retrotransposable
FT                   element R1DM"
FT                   /id="PRO_0000066085"
FT   DOMAIN          479..741
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00405"
FT   REGION          955..971
FT                   /note="Gag-like cysteine motif"
SQ   SEQUENCE   1021 AA;  114932 MW;  F057262D00EAAA57 CRC64;
     TLMFSFIQAN CGRGRAATIE LGVRLRRSES MFALVQEPYL GGDEMDVLPE GMRVFTDRRG
     KAAILVDHQE AICMPVETLT TDYGVCLVVK GSFGSIFLCA AYCQFDAPLE PYLRYMDAVL
     LQASRTPAIL GLDANAVSPM WLSKLSRHAE GQANYRRGEL LSEWMLEARV AALNQSTEVY
     TFDNHRATSD IDVTIVNEAA SMWATYEWRV DEWELSDHNI ITVVAEPTTA RSVESIAPVP
     SWNFSNARWR LFKEEMVSRI AELPENFSES PLDQQVSTLR SIVHSVCDTA LGRKLTRSPS
     RRARWWTADL CAARREVRRL RRLLQDGRRR DDDAAVELVV VELRRASAYY KKLIGRAKMD
     DWKRFVGDHA DDPWGRVYKI CRGRRKCTEI GCLRVNGELI TDWGDCARVL LRNFFPVAES
     EAPTAIAEEV PPALEVFEVD TCVARLKSRR SPGLDGINGT ICKAVWRAIP EHLASLFSRC
     IRLGYFPAEW KCPRVVSLLK GPDKDKCEPS SYRGICLLPV FGKVLEAIMV NRVREVLPEG
     CRWQFGFRQG RCVEDAWRHV KSSVGASAAQ YVLGTFVDFK GAFDNVEWSA ALSRLADLGC
     REMGLWQSFF SGRRAVIRSS SGTVEVPVTR GCPQGSISGP FIWDILMDVL LQRLQPYCQL
     SAYADDLLLL VEGNSRAVLE EKGAQLMSIV ETWGAEVGDC LSTSKTVIML LKGALRRAPT
     VRFAGRNLPY VRSCRYLGIT VSEGMKFLTH IASLRQRMTG VVGALARVLR ADWGFSPRAR
     RTIYDGLMAP CVLFGAPVWY DTAEQVAAQR RLASCQRLIL LGCLSVCRTV STVALQVLGG
     APPLDLAAKL LAIKYKLKRG FPLEENDWLY GEDIACLSWE QRKTRLEECL IQSWQNRWDD
     DSEPGRVTHR FIPYVTLAYR DPSFGFSMRT SFLLTGHGSF NAFLHGRALS DTTACACGDP
     YEDWMHILCA CPLYADLRDL DGLGVQRLGE NWIFEGILDD QEKTQRLAMF AEEVFLRRRA
     L