ID   Y300_METJA              Reviewed;         296 AA.
AC   Q57748;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator MJ0300;
GN   OrderedLocusNames=MJ0300;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; L77117; AAB98287.1; -; Genomic_DNA.
DR   PIR; E64337; E64337.
DR   RefSeq; WP_010869798.1; NC_000909.1.
DR   AlphaFoldDB; Q57748; -.
DR   SMR; Q57748; -.
DR   STRING; 243232.MJ_0300; -.
DR   PRIDE; Q57748; -.
DR   DNASU; 1451155; -.
DR   EnsemblBacteria; AAB98287; AAB98287; MJ_0300.
DR   GeneID; 1451155; -.
DR   KEGG; mja:MJ_0300; -.
DR   eggNOG; arCOG00224; Archaea.
DR   HOGENOM; CLU_039613_6_1_2; -.
DR   InParanoid; Q57748; -.
DR   OMA; IEGPCHH; -.
DR   OrthoDB; 47614at2157; -.
DR   PhylomeDB; Q57748; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..296
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   MJ0300"
FT                   /id="PRO_0000105831"
FT   DOMAIN          1..60
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        20..39
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   296 AA;  33111 MW;  13474BFF48985038 CRC64;
     MDPKISYFQT FIVASKTKSF SKAAKRLGIT QGTVSNHISA LEKYFDAQLF LRTPEGVDLT
     PEGKIFYERA EKILDLLNEA KLLMRAIHEN PEGIIRIYAS TTPGEHILPS IIKEYKSSYK
     NVDFEITITD SERCFKALDE GLADIAAVGY LKNKNYEYTI IGKDRLVLIV PPNHPLAEKG
     TAKLEDILKE DYIDREEGSG TREAFIKALN DKGYSIMDLN VVMRLGSHSA VITAVSEGYG
     VSVVSEIPAK KAEDAGLIKI VPVVDLDVVR YLYLVKSRRP KNPSAVKSFW EFVTKV