ID   Y3030_MYCTU             Reviewed;         274 AA.
AC   P9WJZ1; L0TE97; O53277; Q7D695;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Probable S-adenosylmethionine-dependent methyltransferase Rv3030;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=Rv3030;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Probable S-adenosylmethionine-dependent methyltransferase
CC       required for the 6-O-methylation of the polysaccharide backbone of 6-O-
CC       methylglucosyl lipopolysaccharides (MGLP). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP45838.1; -; Genomic_DNA.
DR   PIR; A70859; A70859.
DR   RefSeq; NP_217546.1; NC_000962.3.
DR   RefSeq; WP_003415922.1; NZ_NVQJ01000011.1.
DR   AlphaFoldDB; P9WJZ1; -.
DR   SMR; P9WJZ1; -.
DR   STRING; 83332.Rv3030; -.
DR   PaxDb; P9WJZ1; -.
DR   DNASU; 888604; -.
DR   GeneID; 888604; -.
DR   KEGG; mtu:Rv3030; -.
DR   TubercuList; Rv3030; -.
DR   eggNOG; COG2227; Bacteria.
DR   OMA; HEVVYQR; -.
DR   PhylomeDB; P9WJZ1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0008168; F:methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0097697; F:tRNA 5-carboxymethoxyuridine methyltransferase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR013216; Methyltransf_11.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF08241; Methyltransf_11; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   1: Evidence at protein level;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..274
FT                   /note="Probable S-adenosylmethionine-dependent
FT                   methyltransferase Rv3030"
FT                   /id="PRO_0000413014"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   274 AA;  29984 MW;  E50314FC7518FD0A CRC64;
     MCAFVPHVPR HSRGDNPPSA STASPAVLTL TGERTIPDLD IENYWFRRHQ VVYQRLAPRC
     TARDVLEAGC GEGYGADLIA CVARQVIAVD YDETAVAHVR SRYPRVEVMQ ANLAELPLPD
     ASVDVVVNFQ VIEHLWDQAR FVRECARVLR GSGLLMVSTP NRITFSPGRD TPINPFHTRE
     LNADELTSLL IDAGFVDVAM CGLFHGPRLR DMDARHGGSI IDAQIMRAVA GAPWPPELAA
     DVAAVTTADF EMVAAGHDRD IDDSLDLIAI AVRP